State-related functional integration and functional segregation brain networks in schizophrenia

	State-related functional integration and functional segregation brain networks in schizophrenia
	Yu, Qingbao 1; Sui, Jing1,7,8 ; Kiehl, Kent A.1,2; Pearlson, Godfrey 3,4,5; Calhoun, Vince D.1,3,4,6
刊名	SCHIZOPHRENIA RESEARCH
	2013-11-01
卷号	150 期号:2-3 页码:450-458
关键词	Brain graph Brain state Integration Segregation Schizophrenia ICA
英文摘要	Altered topological properties of brain connectivity networks have emerged as important features of schizophrenia. The aim of this study was to investigate how the state-related modulations to graph measures of functional integration and functional segregation brain networks are disrupted in schizophrenia. Firstly, resting state and auditory oddball discrimination (AOD) fMRI data of healthy controls (HCs) and schizophrenia patients (SZs) were decomposed into spatially independent components (ICs) by group independent component analysis (ICA). Then, weighted positive and negative functional integration (inter-component networks) and functional segregation (intra-component networks) brain networks were built in each subject. Subsequently, connectivity strength, clustering coefficient, and global efficiency of all brain networks were statistically compared between groups (HCs and SZs) in each state and between states (rest and AOD) within group. We found that graph measures of negative functional integration brain network and several positive functional segregation brain networks were altered in schizophrenia during AOD task. The metrics of positive functional integration brain network and one positive functional segregation brain network were higher during the resting state than during the AOD task only in HCs. These findings imply that state-related characteristics of both functional integration and functional segregation brain networks are impaired in schizophrenia which provides new insight into the altered brain performance in this brain disorder. (C) 2013 Elsevier B. V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Psychiatry
研究领域[WOS]	Psychiatry
关键词[WOS]	INDEPENDENT COMPONENT ANALYSIS ; SMALL-WORLD NETWORKS ; FMRI DATA ; DEFAULT-MODE ; CONNECTIVITY NETWORKS ; BLIND SEPARATION ; BIPOLAR DISORDER ; DARK ENERGY ; GROUP PICA ; MRI DATA
收录类别	SCI ; SSCI
语种	英语
WOS记录号	WOS:000326180700022
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3225]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Mind Res Network, Albuquerque, NM 87106 USA 2.Univ New Mexico, Dept Psychol, Albuquerque, NM 87106 USA 3.Olin Neuropsychiat Res Ctr, Hartford, CT 06106 USA 4.Yale Univ, Dept Psychiat, New Haven, CT 06520 USA 5.Yale Univ, Dept Neurobiol, New Haven, CT 06520 USA 6.Univ New Mexico, Dept ECE, Albuquerque, NM 87106 USA 7.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 8.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Yu, Qingbao,Sui, Jing,Kiehl, Kent A.,et al. State-related functional integration and functional segregation brain networks in schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2013,150(2-3):450-458.
APA	Yu, Qingbao,Sui, Jing,Kiehl, Kent A.,Pearlson, Godfrey,&Calhoun, Vince D..(2013).State-related functional integration and functional segregation brain networks in schizophrenia.SCHIZOPHRENIA RESEARCH,150(2-3),450-458.
MLA	Yu, Qingbao,et al."State-related functional integration and functional segregation brain networks in schizophrenia".SCHIZOPHRENIA RESEARCH 150.2-3(2013):450-458.