Alteration of resting brain function by genetic variation in angiotensin converting enzyme in amnestic-type mild cognitive impairment of Chinese Han

	Alteration of resting brain function by genetic variation in angiotensin converting enzyme in amnestic-type mild cognitive impairment of Chinese Han
	Zhang, Zhengsheng 1,2; Deng, Linglong 2; Bai, Feng 2; Shi, Yongmei 1,2; Yu, Hui 2; Yuan, Yonggui 3; Wang, Kun 4; Jiang, Tianzi4 ; Jia, Jianping 5; Zhang, Zhijun 1,2
刊名	BEHAVIOURAL BRAIN RESEARCH
	2010-04-02
卷号	208 期号:2 页码:619-625
关键词	Mild cognitive impairment Angiotensin converting enzyme I/D polymorphism Cognitive function Magnetic resonance imaging
英文摘要	Using a cross-sectional case-control study of amnestic-mild cognitive impairment (aMCI), we characterised the relationships among cognitive function, serum levels of angiotensin converting enzyme (ACE), brain activity, and ACE insertion or deletion (VD) polymorphism. Forty-eight patients with aMCI and 36 well-matched normal controls were assessed by a comprehensive battery of standardized neuropsychological tests. In addition, regional homogeneity (ReHo) approaches were used to analyze blood oxygen level-dependent functional magnetic resonance imaging data on the resting state in all subjects, and genotyping of the serum ACE was measured in aMCI patients. The D carriers with aMCI patients were found to have markedly higher serum ACE levels than I homozygote carriers. Importantly, compared with the carried I homozygote group of patients with aMCI, the D carriers of aMCI patients were significantly impaired in the AVLT-delayed recall and had decreased ReHo over the bilateral precuneus, left middle occipital gyrus, right inferior parietal lobe, and right angular gyrus, whilst increased ReHo was found mainly in the left medial frontal gyrus, right paracentral lobe, and right anterior cingulate cortex. The findings indicated that ACE genotype was associated with episodic memory, serum levels of ACE, and resting-state brain activity in aMCI patients, and the findings of cognitive function and brain activity further suggests that the ACED allele may have a specific role in semantic memory dysfunction and brain activity in aMCI. Published by Elsevier By.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Behavioral Sciences ; Neurosciences
研究领域[WOS]	Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]	INSERTION DELETION POLYMORPHISM ; ALZHEIMERS-DISEASE ; DEFAULT-MODE ; DANISH TWINS ; ACE ; GENOTYPE ; SYSTEM ; SUSCEPTIBILITY ; POPULATION ; INHIBITORS
收录类别	SCI
语种	英语
WOS记录号	WOS:000276621200042
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3102]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Southeast Univ, Affiliated ZhongDa Hosp, Dept Neurol, Nanjing 210009, Peoples R China 2.Southeast Univ, Sch Clin Med, Nanjing 210009, Peoples R China 3.Nanjing Med Univ, Nanjing Brain Hosp, Dept Psychiat, Nanjing 210029, Peoples R China 4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China 5.Capital Med Univ, Xuan Wu Hosp, Dept Neurol, Beijing 100053, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zhengsheng,Deng, Linglong,Bai, Feng,et al. Alteration of resting brain function by genetic variation in angiotensin converting enzyme in amnestic-type mild cognitive impairment of Chinese Han[J]. BEHAVIOURAL BRAIN RESEARCH,2010,208(2):619-625.
APA	Zhang, Zhengsheng.,Deng, Linglong.,Bai, Feng.,Shi, Yongmei.,Yu, Hui.,...&Zhang, Zhijun.(2010).Alteration of resting brain function by genetic variation in angiotensin converting enzyme in amnestic-type mild cognitive impairment of Chinese Han.BEHAVIOURAL BRAIN RESEARCH,208(2),619-625.
MLA	Zhang, Zhengsheng,et al."Alteration of resting brain function by genetic variation in angiotensin converting enzyme in amnestic-type mild cognitive impairment of Chinese Han".BEHAVIOURAL BRAIN RESEARCH 208.2(2010):619-625.