ACE I/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment

	ACE I/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment
	Zhang, Zhengsheng 1,2,3; Deng, Linglong 1; Bai, Feng 1; Shi, Yongmei 1,2,3; Yu, Hui 1; Yuan, Yonggui 4; Jiang, Tianzi5 ; Jia, Jianping 6; Zhang, Zhijun 1,2,3
刊名	BEHAVIOURAL BRAIN RESEARCH
	2011-03-17
卷号	218 期号:1 页码:114-120
关键词	Mild cognitive impairment Angiotensin converting enzyme I/D polymorphism Cognitive function Magnetic resonance imaging Voxel-based morphometry
英文摘要	To characterize the correlates of cognitive function, serum concentrations of angiotensin converting enzyme (ACE) and brain structure with the ACE insertion or deletion (VD) polymorphism were analyzed in subjects with amnestic-mild cognitive impairment (aMCI). A group of 48 subjects meeting criteria for aMCI and 36 age-matched control subjects were assessed using a comprehensive battery of standardized neuropsychological tests and magnetic resonance imaging (MRI). The ACE gene's I/D polymorphism was analyzed by means of PCR, and serum ACE concentrations were measured using ultraviolet spectrophotometry. Genotype effects on neuropsychological domains and MRI gray matter volume (GMV) measurements (optimized voxel-based morphometry) were examined using general linear models. The D carriers among the aMCI subjects performed significantly worse on AVLT-delayed recall compared to the I homozygous group. The D carriers had higher serum ACE concentrations than did the I homozygous carriers, though this difference only reached statistical significance in the aMCI group. Compared with the I homozygous carriers, in the aMCI group, D carriers showed smaller GMV of the bilateral middle frontal gyrus, right cuneus, right precentral gyrus, right medial frontal gyrus, right superior frontal gyrus, and left postcentral gyrus. However, there was no significant difference in GMV between I homozygous and D carriers in the normal control group. The study suggests that ACE genotype has considerable effect on the cognitive performance of aMCI subjects, particularly episodic memory, serum activity of ACE, and the structure of specified brain regions. The ACE D allele may be a genetic risk factor for greater atrophy of gray matter in aMCI. (C) 2010 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Behavioral Sciences ; Neurosciences
研究领域[WOS]	Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]	ANGIOTENSIN-CONVERTING ENZYME ; INSERTION-DELETION POLYMORPHISM ; VOXEL-BASED MORPHOMETRY ; ALZHEIMERS-DISEASE ; MEMORY IMPAIRMENT ; ENTORHINAL CORTEX ; GENETIC-VARIATION ; BRAIN ATROPHY ; CHINESE-HAN ; HIPPOCAMPUS
收录类别	SCI
语种	英语
WOS记录号	WOS:000289137200016
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3100]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Southeast Univ, Sch Clin Med, Nanjing 210009, Peoples R China 2.Nanjing Univ, Affiliated ZhongDa Hosp, Dept Neurol, Nanjing 210009, Peoples R China 3.Southeast Univ, Inst Neuropsychiat Res, Nanjing 210009, Peoples R China 4.Nanjing Med Univ, Affiliated Nanjing Brain Hosp, Dept Psychiat, Nanjing 210029, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China 6.Capital Med Univ, Xuan Wu Hosp, Dept Neurol, Beijing 100053, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zhengsheng,Deng, Linglong,Bai, Feng,et al. ACE I/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment[J]. BEHAVIOURAL BRAIN RESEARCH,2011,218(1):114-120.
APA	Zhang, Zhengsheng.,Deng, Linglong.,Bai, Feng.,Shi, Yongmei.,Yu, Hui.,...&Zhang, Zhijun.(2011).ACE I/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment.BEHAVIOURAL BRAIN RESEARCH,218(1),114-120.
MLA	Zhang, Zhengsheng,et al."ACE I/D polymorphism affects cognitive function and gray-matter volume in amnestic mild cognitive impairment".BEHAVIOURAL BRAIN RESEARCH 218.1(2011):114-120.