Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD

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	Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD
	Li Juan; Yu Jing; Niu Ya-Nan
刊名	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
	2012-08-01
卷号	39 期号:8 页码:804-810
关键词	Alzheimer's disease mild cognitive impairment early detection neuropsychology intervention
ISSN号	1000-3282
通讯作者	Li, J (reprint author), Chinese Acad Sci, Ctr Ageing Psychol, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
产权排序	1
英文摘要	Mild cognitive impairment (MCI) is an intermediate clinical state between normal aging and dementia, and MCI patients are the risk population for the development of Alzheimer's disease (AD). This article firstly introduced the international diagnosis criteria of MCI and its variations and modifications, and based on the previous findings, we proposed an ideal diagnosis model for MCI detection in which outmeasures included both patient's self-report, clinician's judgment and objective behavioral and neuropsychological tests as well as various biomarkers through advanced imaging techniques, cerebrospinal fluid analysis, or even urine endogenous formaldehyde analysis, both cross-sectional comparisons of an individual with the norms and longitudinal changes derived from multi-time point measurements were also involved. We reviewed the recent studies on the neuropsychological impairment characteristics of MCI and the corresponding measurement tools from both cognitive and neuropsychiatric aspects such as MMSE, MoCA, NPI and SCID, and various cognitive intervention methods for MCI were also reviewed. Future research is needed to extend the findings from experimental small samples into community-based large population, as well as from the cross-sectional studies into longitudinal studies, and to adopt multi-detection markers and multi-intervention methods to achieve the optimal effects of early detection and intervention of MCI.
学科主题	Abnormal psychology
收录类别	SCI
项目简介	This work was supported by grants from The National Natural Science Foundation of China (30770725, 31070916), National Science & Technology Pillar Program of China (2009BAI77B03) and Knowledge Innovation Project of The Chinese Academy of Sciences (KSCX2-EW-J-8).
语种	英语
WOS记录号	WOS:000307851900019
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/12876]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	Chinese Acad Sci, Ctr Ageing Psychol, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Li Juan,Yu Jing,Niu Ya-Nan. Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2012,39(8):804-810.
APA	Li Juan,Yu Jing,&Niu Ya-Nan.(2012).Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,39(8),804-810.
MLA	Li Juan,et al."Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 39.8(2012):804-810.