An antimicrobial peptide gene found in the male reproductive system of rats

	An antimicrobial peptide gene found in the male reproductive system of rats
	Li, P; Chan, HC; He, B; So, SC; Chung, YW; Shang, Q; Zhang, YD; Zhang, YL
刊名	SCIENCE
	2001
卷号	291 期号:5509 页码:1783-1785
通讯作者	Zhang, YL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,
英文摘要	Little is known about the innate defense mechanisms of the male reproductive tract. We cloned a 385-base pair complementary DNA and its genomic DNA named Bin1b that is exclusively expressed in the caput region of the rat epididymis and that is responsible for sperm maturation, storage, and protection. Bin1b exhibits structural characteristics and antimicrobial activity similar to that of cationic antimicrobial peptides, beta -defensins. Bin1b is maximally expressed when the rats are sexually mature and can be up-regulated by inflammation. Bin1b appears to be a natural epididymis-specific antimicrobial peptide that plays a role in reproductive tract host defense and male fertility.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	INNATE HOST-DEFENSE ; CHLAMYDIA-TRACHOMATIS ; ANION SECRETION ; MESSENGER-RNA ; EPIDIDYMIS ; ANTIBIOTICS ; EPITHELIA ; BETA-DEFENSIN-1 ; EXPRESSION ; CHANNEL
收录类别	SCI
语种	英语
WOS记录号	WOS:000167320600058
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2722]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Li, P,Chan, HC,He, B,et al. An antimicrobial peptide gene found in the male reproductive system of rats[J]. SCIENCE,2001,291(5509):1783-1785.
APA	Li, P.,Chan, HC.,He, B.,So, SC.,Chung, YW.,...&Zhang, YL.(2001).An antimicrobial peptide gene found in the male reproductive system of rats.SCIENCE,291(5509),1783-1785.
MLA	Li, P,et al."An antimicrobial peptide gene found in the male reproductive system of rats".SCIENCE 291.5509(2001):1783-1785.