Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates

	Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates
	Pu, L; Bao, GB; Xu, NJ; Ma, L; Pei, G
刊名	JOURNAL OF NEUROSCIENCE
	2002
卷号	22 期号:5 页码:1914-1921
关键词	opiate rat hippocampus long-term potentiation cAMP addiction
通讯作者	Pei, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,
英文摘要	Chronic exposure to opiates eventually leads to drug addiction, which is believed to involve maladaptive changes in brain function, but the underlying neuronal mechanisms remain primarily unknown. Given the known effects of opiates such as morphine and heroin on hippocampal function, we investigated the potential effect of chronic opiate treatment on long-term potentiation (LTP) at CA1 synapses in rat hippocampus, a leading experimental model for studying synaptic plasticity. Our results revealed that chronic exposure of rats to morphine or heroin, which induced severe drug tolerance and dependence, markedly reduced the capacity of hippocampal CA1 LTP during the period of drug withdrawal (from similar to190% in control to similar to120%). More interestingly, the capacity of LTP could be restored to the normal level by re-exposure of the animals to opiates, indicating that the synaptic function was already adapted to opiates. Morris water maze test, which measures behavioral consequences of synaptic plasticity, showed parallel learning deficits after chronic exposure to opiates. Moreover, the opiate-reduced LTP could also be restored by inhibitors of cAMP-dependent protein kinase A (PKA), suggesting that up-regulation of cAMP pathway was likely one of the underlying mechanisms of the observed phenomena. These findings demonstrated that chronic opiate treatment can significantly modulate synaptic plasticity in the hippocampus, leading to an opiate dependence of the plasticity.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	DEPENDENT PROTEIN-KINASE ; MORPHINE-TOLERANCE ; RAT HIPPOCAMPUS ; PHOSPHORYLATION SITES ; RECEPTOR ANTAGONIST ; NUCLEUS-ACCUMBENS ; OPIOID RECEPTORS ; ADDICTION ; LTP ; NEUROSCIENCE
收录类别	SCI
语种	英语
WOS记录号	WOS:000174192500046
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2512]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Pu, L,Bao, GB,Xu, NJ,et al. Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates[J]. JOURNAL OF NEUROSCIENCE,2002,22(5):1914-1921.
APA	Pu, L,Bao, GB,Xu, NJ,Ma, L,&Pei, G.(2002).Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates.JOURNAL OF NEUROSCIENCE,22(5),1914-1921.
MLA	Pu, L,et al."Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates".JOURNAL OF NEUROSCIENCE 22.5(2002):1914-1921.