Induction of tyrosine hydroxylase expression in rat fetal striatal precursor cells following transplantation

	Induction of tyrosine hydroxylase expression in rat fetal striatal precursor cells following transplantation
	Tang, ZS; Yu, Y; Guo, H; Zhou, JW
刊名	NEUROSCIENCE LETTERS
	2002
卷号	324 期号:1 页码:13-16
关键词	neural precursor cell differentiation tyrosine hydroxylase transplantation
通讯作者	Zhou, JW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,
英文摘要	Differentiation of neural stem cells into tyrosine hydroxylase (TH)-expressing cells was studied by cell transplantation into the various brain regions of rats that had received 6-hydroxydopamine lesion of the nigrostriatal pathway. Approximately 13.6-16.1% of survived precursor cells acquired neuronal-like features by expressing the neuronal marker doublecortin. Similarly, 20.7-25.7% of survived precursor cells differentiated into astrocytes following transplantation. Immunohistochemical analysis revealed that a fraction of the grafted precursor cells in the anterior part of the medial forebrain bundle (MFB), but not in the striatum and the substantia nigra of the lesioned side, showed strong TH immunoreactivity. This suggests that MFB is more permissive for induction of TH to the striatal precursor cells in vivo. The results further exemplify the potential of neural stem cells and the property of site-specific differentiation when the cells were transplanted to the dopaminergic system of the adult brain. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	NEURAL PROGENITOR CELLS ; DOPAMINERGIC-NEURONS ; ADULT BRAIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000175793000004
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2411]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Tang, ZS,Yu, Y,Guo, H,et al. Induction of tyrosine hydroxylase expression in rat fetal striatal precursor cells following transplantation[J]. NEUROSCIENCE LETTERS,2002,324(1):13-16.
APA	Tang, ZS,Yu, Y,Guo, H,&Zhou, JW.(2002).Induction of tyrosine hydroxylase expression in rat fetal striatal precursor cells following transplantation.NEUROSCIENCE LETTERS,324(1),13-16.
MLA	Tang, ZS,et al."Induction of tyrosine hydroxylase expression in rat fetal striatal precursor cells following transplantation".NEUROSCIENCE LETTERS 324.1(2002):13-16.