Estimating coarse gene networks from yeast gene expression time series

	Estimating coarse gene networks from yeast gene expression time series
	Xu, XJ; Wang, LS; Ding, DF
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2003
卷号	35 期号:8 页码:707-716
关键词	gene regulatory network genome time serial expression cell cycle environmental stress
通讯作者	Ding, DF (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Proteom, Shanghai 200031, Peoples R China.,dingdafu@server.shcnc.ac.cn
英文摘要	Gene networks is the collection of gene-gene regulatory relations at the expression level. In this study,. a combined approach of the linear transcriptional modeling, identification of promoter elements and gene co-expression clustering is developed to decipher yeast gene networks from expression time series. The cell must reorganize the genomic expression to programs required for growth and survival in each environment. The expression of many genes is regulated by environmental stress. The products of many genes that induced in the environmental stress are involved in metabolism of carbohydrates, structural repairs and even sporulation. Interestingly, it is identified that transcription factors Mcm1 and Dal82 matched their binding sites TT-CC---T--GGAAA and TGAAAAWTTT in cell cycle progression and environmental stress response, respectively. These conclusions agree with the known observations. The results indicate that the approach may be useful for modeling gene networks from microarray data.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	TRANSCRIPTIONAL REGULATORY NETWORKS ; SACCHAROMYCES-CEREVISIAE ; CELL-CYCLE ; PROTEIN
收录类别	SCI
语种	中文
WOS记录号	WOS:000184988600005
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2328]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Xu, XJ,Wang, LS,Ding, DF. Estimating coarse gene networks from yeast gene expression time series[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2003,35(8):707-716.
APA	Xu, XJ,Wang, LS,&Ding, DF.(2003).Estimating coarse gene networks from yeast gene expression time series.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,35(8),707-716.
MLA	Xu, XJ,et al."Estimating coarse gene networks from yeast gene expression time series".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 35.8(2003):707-716.