Modification of hippocampal neurogenesis and neuroplasticity by social environments

	Modification of hippocampal neurogenesis and neuroplasticity by social environments
	Lu, L; Bao, GB; Chen, H; Xia, P; Fan, XL; Zhang, JS; Pei, G; Ma, L
刊名	EXPERIMENTAL NEUROLOGY
	2003
卷号	183 期号:2 页码:600-609
关键词	social environments neurogenesis long-term potentiation synaptic plasticity hippocampus isolation learning and memory
通讯作者	Ma, L (reprint author), Fudan Univ, Shanghai Med Coll, Natl Lab Med Neurobiol, 138 Yi Xue Yuan Rd, Shanghai 200032, Peoples R China.,
英文摘要	Synaptic plasticity and neurogenesis in the brain are affected by environmental stimuli. The present study was designed to investigate the effects of social environments on learning and memory, neurogenesis, and neuroplasticity. Twenty-two-day-old rats were housed in isolation or in groups for 4 or 8 weeks and injected intraperitoneally with bromodeoxyuridine to detect proliferation among progenitor cells. The animals were also tested for learning in a water maze and for hippocampal CA1 long-term potentiation in vivo and in vitro. The results show that the number of newborn neurons in the dentate gyrus and the learning in a water maze decreased significantly in rats reared in isolation for 4 or 8 weeks, as compared with grouped controls. Induction of long-term potentiation in the CA1 area of rat hippocampus in vivo and in vitro was also significantly reduced by isolation. Furthermore, the effects of isolation rearing on spatial learning, hippocampal neurogenesis, and long-term potentiation could be reversed by subsequent group rearing. These findings demonstrated that social environments can modify neurogenesis and synaptic plasticity in adult hippocampal regions, which is associated with alterations in spatial learning and memory. (C) 2003 Elsevier Science (USA). All rights reserved.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	LONG-TERM POTENTIATION ; RAT DENTATE GYRUS ; NMDA RECEPTOR ACTIVATION ; ADULT-RAT ; INCREASES NEUROGENESIS ; ENRICHED ENVIRONMENT ; SYNAPTIC PLASTICITY ; NEURONS ; STRESS ; MICE
收录类别	SCI
语种	英语
WOS记录号	WOS:000185724600037
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2244]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Lu, L,Bao, GB,Chen, H,et al. Modification of hippocampal neurogenesis and neuroplasticity by social environments[J]. EXPERIMENTAL NEUROLOGY,2003,183(2):600-609.
APA	Lu, L.,Bao, GB.,Chen, H.,Xia, P.,Fan, XL.,...&Ma, L.(2003).Modification of hippocampal neurogenesis and neuroplasticity by social environments.EXPERIMENTAL NEUROLOGY,183(2),600-609.
MLA	Lu, L,et al."Modification of hippocampal neurogenesis and neuroplasticity by social environments".EXPERIMENTAL NEUROLOGY 183.2(2003):600-609.