SNAP-25 in hippocampal CA1 region is involved in memory consolidation

	SNAP-25 in hippocampal CA1 region is involved in memory consolidation
	Hou, QL; Gao, X; Zhang, XH; Kong, LW; Wang, XM; Bian, W; Tu, YY; Jin, ML; Zhao, GP; Li, BM
刊名	EUROPEAN JOURNAL OF NEUROSCIENCE
	2004
卷号	20 期号:6 页码:1593-1603
关键词	antisense oligonucleotides hippocampus long-term potentiation memory rat SNAP-25
通讯作者	Yu, L (reprint author), Univ Cincinnati, Coll Med, Dept Anat Cell Biol & Neurobiol, 3125 Eden Ave, Cincinnati, OH 45267 USA.,lei.yu@uc.edu
英文摘要	As a synaptosomal protein, SNAP-25 plays a role in a number of neuronal functions including axonal growth, dendrite formation, fusion of synaptic vesicles with membrane and the expression of long-term potentiation (LTP) in the hippocampus. Using a learning/memory behavior screening, we identified SNAP-25 as one of the differentially expressed genes in the hippocampus upon behavioral training. The inhibition of SNAP-25 with intracerebroventricular antisense oligonucleotide caused a deficit in long- but not short-term memory for step-down inhibitory avoidance. Intra-CA1 infusion of the SNAP-25 antisense oligonucleotide impaired long-term contextual fear memory and spatial memory and interfered with the LTP of synaptic transmission in the CA1 region. The inhibitory effect on LTP was not mediated by a pre-synaptic mechanism because paired pulse facilitation of synaptic transmission was not affected after administration of the antisense oligonucleotide. Together, the results suggest that SNAP-25 in the CA1 region is involved in memory consolidation.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	LONG-TERM POTENTIATION ; ASPARTATE RECEPTOR ANTAGONIST ; CONTEXTUAL FEAR ; SYNAPTIC PLASTICITY ; SELECTIVE IMPAIRMENT ; MEDIATED DISRUPTION ; DORSAL HIPPOCAMPUS ; RETROGRADE-AMNESIA ; RAT HIPPOCAMPUS ; WATER MAZE
收录类别	SCI
语种	英语
WOS记录号	WOS:000223744600017
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2095]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Hou, QL,Gao, X,Zhang, XH,et al. SNAP-25 in hippocampal CA1 region is involved in memory consolidation[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2004,20(6):1593-1603.
APA	Hou, QL.,Gao, X.,Zhang, XH.,Kong, LW.,Wang, XM.,...&Yu, L.(2004).SNAP-25 in hippocampal CA1 region is involved in memory consolidation.EUROPEAN JOURNAL OF NEUROSCIENCE,20(6),1593-1603.
MLA	Hou, QL,et al."SNAP-25 in hippocampal CA1 region is involved in memory consolidation".EUROPEAN JOURNAL OF NEUROSCIENCE 20.6(2004):1593-1603.