Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1 alpha-induced leukocytes chemotaxis

	Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1 alpha-induced leukocytes chemotaxis
	Ji, LL; Wang, Z; Dong, F; Zhang, WB; Wang, ZT
刊名	JOURNAL OF CELLULAR BIOCHEMISTRY
	2005
卷号	95 期号:5 页码:970-978
关键词	andrograpanin chemokine leukocyte SDF-1 alpha CXCR4 chemotaxis internalization
通讯作者	Wang, ZT (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,herbs@mailbox.cpu.edu.cn
英文摘要	Andrographis paniculata is a traditional Chinese medicine (TCM) that has been effectively used for treatment of infection, inflammation, cold, fever, and diarrhea in China. However, mechanism of its therapeutic function is not well known. In the current study, we showed one of its components, andrograpanin, could enhance chemokine stromal cell-derived factor-1 alpha (SDF-1 alpha) induced chemotaxis in Jurkat and THP-1 cells. Further study demonstrated that this kind of effect was CXC chemokine receptor-4 (CXCR4) specific, since andrograpanin could not enhance other chemokines, such as RANTES, monocyte chemotactic protein-1 (MCP-1), etc. induced cell chemotaxis. Mechanisms of andrograpanin exerting its effect were not directly in the receptor and G protein coupling level because it had no effect on the binding of SDF-1 to CXCR4, SDF-1 induced G protein activation and adenyly cyclase inhibition. However, receptor internalization might be involved, since we found it significantly reduced SDF-1 alpha-induced CXCR4 internalization.
学科主题	Biochemistry & Molecular Biology; Cell Biology
类目[WOS]	Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]	NITRIC-OXIDE SYNTHASE ; RECEPTOR CXCR4 ; TRANSENDOTHELIAL MIGRATION ; FUNCTIONAL EXPRESSION ; CELL CHEMOTAXIS ; ADHESION ; PROTEIN ; SUPPRESSION ; ACTIVATION ; INTERNALIZATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000230960900009
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1911]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Ji, LL,Wang, Z,Dong, F,et al. Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1 alpha-induced leukocytes chemotaxis[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2005,95(5):970-978.
APA	Ji, LL,Wang, Z,Dong, F,Zhang, WB,&Wang, ZT.(2005).Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1 alpha-induced leukocytes chemotaxis.JOURNAL OF CELLULAR BIOCHEMISTRY,95(5),970-978.
MLA	Ji, LL,et al."Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1 alpha-induced leukocytes chemotaxis".JOURNAL OF CELLULAR BIOCHEMISTRY 95.5(2005):970-978.