Xenopus Tbx6 mediates posterior patterning via activation of Wnt and FGF signalling

	Xenopus Tbx6 mediates posterior patterning via activation of Wnt and FGF signalling
	Lou, X; Fang, PF; Li, SW; Hu, RY; Kuerner, KM; Stembeisser, H; Ding, XY
刊名	CELL RESEARCH
	2006
卷号	16 期号:9 页码:771-779
关键词	posterior patterning XTbx6 wnt FGF
通讯作者	Ding, XY (reprint author), Chinese Acad Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Grad Sch, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xyding@sumn.shcnc.ac.cn
英文摘要	In vertebrates, the patterning of antenior-postenior (AP) axis is a fundamental process during embryogenesis. Wnt and FGF signalling pathways play important roles in regulating the patterning of embryo AP axis. Mouse Thx6 encodes a transcription factor that has been demonstrated to be involved in the specification of the posterior tissue in mouse embryonic body. Here, we prove that morpholino-induced knockdown of XTbx6 impairs posterior development, indicating the requirement of XTbx6 in this process. Meanwhile, gain of XTbx6 function is sufficient to induce ectopic posterior structures in Xenopus embryos. Furthermore, XTbx6 activates the expression of Xwnt8 and FGF8, which are two mediators of posterior development, suggesting a mechanism by which XTbx6 modulates posterior patterning via Wnt and FGF signalling pathway activation.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	BOX GENE TBX6 ; TAIL BUD ; MOUSE EMBRYO ; MESODERM SPECIFICATION ; LIMB REGENERATION ; EXPRESSION ; INDUCTION ; OUTGROWTH ; LAEVIS ; CELLS
收录类别	SCI
语种	英语
WOS记录号	WOS:000241489800005
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1760]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Lou, X,Fang, PF,Li, SW,et al. Xenopus Tbx6 mediates posterior patterning via activation of Wnt and FGF signalling[J]. CELL RESEARCH,2006,16(9):771-779.
APA	Lou, X.,Fang, PF.,Li, SW.,Hu, RY.,Kuerner, KM.,...&Ding, XY.(2006).Xenopus Tbx6 mediates posterior patterning via activation of Wnt and FGF signalling.CELL RESEARCH,16(9),771-779.
MLA	Lou, X,et al."Xenopus Tbx6 mediates posterior patterning via activation of Wnt and FGF signalling".CELL RESEARCH 16.9(2006):771-779.