Critical regulation of CD4(+) T cell survival and autoimmunity by beta-arrestin 1

	Critical regulation of CD4(+) T cell survival and autoimmunity by beta-arrestin 1
	Shi, YF; Feng, Y; Kang, JH; Liu, C; Li, ZX; Li, DS; Cao, W; Qiu, J; Guo, ZL; Bi, EG
刊名	NATURE IMMUNOLOGY
	2007
卷号	8 期号:8 页码:817-824
通讯作者	Zhang, JZ (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Lab Mol Cell Biol,Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,jwzang@sibs.ac.cn ; gpei@sibs.ac.cn
英文摘要	CD4(+) T cells are important in adaptive immunity, but their dysregulation can cause autoimmunity. Here we demonstrate that the multifunctional adaptor protein beta-arrestin 1 positively regulated naive and activated CD4(+) T cell survival. We found enhanced expression of the proto-oncogene Bcl2 through beta-arrestin 1-dependent regulation of acetylation of histone H4 at the Bcl2 promoter. Mice deficient in the gene encoding beta-arrestin 1 (Arrb1) were much more resistant to experimental autoimmune encephalomyelitis, whereas overexpression of Arrb1 increased susceptibility to this disease. CD4(+) T cells from patients with multiple sclerosis had much higher Arrb1 expression, and 'knockdown' of Arrb1 by RNA-mediated interference in those cells increased apoptosis induced by cytokine withdrawal. Our data demonstrate that beta-arrestin 1 is critical for CD4(+) T cell survival and is a factor in susceptibility to autoimmunity.
学科主题	Immunology
类目[WOS]	Immunology
关键词[WOS]	NUCLEAR EXPORT SIGNAL ; RECEPTOR-GAMMA CHAIN ; MULTIPLE-SCLEROSIS ; BETA-ARRESTINS ; DOWN-REGULATION ; IMMUNE-SYSTEM ; PROTEIN ; BCL-2 ; ACTIVATION ; EXPRESSION
收录类别	SCI
语种	英语
WOS记录号	WOS:000248169400009
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1589]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Shi, YF,Feng, Y,Kang, JH,et al. Critical regulation of CD4(+) T cell survival and autoimmunity by beta-arrestin 1[J]. NATURE IMMUNOLOGY,2007,8(8):817-824.
APA	Shi, YF.,Feng, Y.,Kang, JH.,Liu, C.,Li, ZX.,...&Pei, G.(2007).Critical regulation of CD4(+) T cell survival and autoimmunity by beta-arrestin 1.NATURE IMMUNOLOGY,8(8),817-824.
MLA	Shi, YF,et al."Critical regulation of CD4(+) T cell survival and autoimmunity by beta-arrestin 1".NATURE IMMUNOLOGY 8.8(2007):817-824.