Post-ischemic continuous administration of galantamine attenuates cognitive deficits and hippocampal neurons loss after transient global ischemia in gerbils

	Post-ischemic continuous administration of galantamine attenuates cognitive deficits and hippocampal neurons loss after transient global ischemia in gerbils
	Ji, XH; Li, CY; Lu, Y; Chen, YY; Guo, LH
刊名	NEUROSCIENCE LETTERS
	2007
卷号	416 期号:1 页码:92-95
关键词	brain ischemia galantamine hippocampus gerbil
通讯作者	Guo, LH (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol,Lab Genet Engn, 320 Yue Yang Rd, Shanghai, Peoples R China.,mhzhang@sunm.Shcnc.ac.cn
英文摘要	The deficits due to global cerebral ischemia show a close correlation with hippocampal CA1 neurons damage. Here we presented that galantamine showed effective protection against ischemic insults. In a transient brain global ischemic model conducted in gerbils, we investigated the alterations of performance in passive avoidance test and the histological changes between sham-operated animals (as controls) and those received post-ischemic continuous administration of saline (vehicle) or galantarnine. Compared to the controls, gerbils received ischemc insults with saline treatment showed significant impairment in performance in passive avoidance test and dramatic loss of cells in hippocampal CA1 region. However, gerbils that received the same insults with galantamine (2 mg/kg/day) treatment performed similarly to the controls. Consistently, most of the cells in hippocampal CA1 region which were vulnerable to ischemic insults, survived after galantamine treatment. Our results suggested that continuous application of galantamine might be effective in treatment of ischemic injury. (c) 2007 Published by Elsevier Ireland Ltd.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	VASCULAR DEMENTIA ; ALZHEIMERS-DISEASE ; GALANTHAMINE ; RATS
收录类别	SCI
语种	英语
WOS记录号	WOS:000246038900018
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1504]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Ji, XH,Li, CY,Lu, Y,et al. Post-ischemic continuous administration of galantamine attenuates cognitive deficits and hippocampal neurons loss after transient global ischemia in gerbils[J]. NEUROSCIENCE LETTERS,2007,416(1):92-95.
APA	Ji, XH,Li, CY,Lu, Y,Chen, YY,&Guo, LH.(2007).Post-ischemic continuous administration of galantamine attenuates cognitive deficits and hippocampal neurons loss after transient global ischemia in gerbils.NEUROSCIENCE LETTERS,416(1),92-95.
MLA	Ji, XH,et al."Post-ischemic continuous administration of galantamine attenuates cognitive deficits and hippocampal neurons loss after transient global ischemia in gerbils".NEUROSCIENCE LETTERS 416.1(2007):92-95.