Role of Toll-like receptors in regulatory functions of T and B cells

	Role of Toll-like receptors in regulatory functions of T and B cells
	Chang, ZL
刊名	CHINESE SCIENCE BULLETIN
	2008
卷号	53 期号:8 页码:1121-1127
关键词	TLRs T cells B cells therapeutic potential
通讯作者	Chang, ZL (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,chang_zong_liang@sibs.ac.cn
英文摘要	Pathogens can find their ways to most sites in the host. Pathogen sensors, such as Toll-like receptors (TLRs), must be equally and broadly distributed on immune cells to combat them through innate and adaptive immunity. Most classes of TLRs are found in innate immune cells to obtain an immediate response against pathogens, but recent studies indicate that a number of TLRs are wildly expressed in T and B cells, suggesting TLRs also directly regulate adaptive immune responses. Due to the rapid increase of new information on the multiple roles of TLRs, in this paper we aim to review several main properties of TLRs and their direct role in T and B cells. This review consists of 6 parts: (i) Characteristics of Toll-like receptors (TLRs) and signaling; (ii) signalling pathways of TLRs; (iii) TLR expressions on human leukocytes; (iv) TLR expressions and functions in the Thl, CD4+CD45RO+ memory T cells and regulatory/suppressor T as well as B cell populations; (v) therapeutic potential of TLR agonists; (Vi) discussion and perspective. The latest findings and potential therapeutic applications are discussed. There is growing evidence supporting the concept that TLR activation contributes not only to innate immunity but also to adaptive immunity, including direct regulation of both T and B lymphocytes by TLRs.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	NONHUMAN-PRIMATES ; LIGAND FLAGELLIN ; INNATE IMMUNITY ; CUTTING EDGE ; EXPRESSION ; RESPONSES ; AGONISTS ; LEUKOCYTES ; DROSOPHILA ; MAGNITUDE
收录类别	SCI
语种	英语
WOS记录号	WOS:000254999100001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1421]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chang, ZL. Role of Toll-like receptors in regulatory functions of T and B cells[J]. CHINESE SCIENCE BULLETIN,2008,53(8):1121-1127.
APA	Chang, ZL.(2008).Role of Toll-like receptors in regulatory functions of T and B cells.CHINESE SCIENCE BULLETIN,53(8),1121-1127.
MLA	Chang, ZL."Role of Toll-like receptors in regulatory functions of T and B cells".CHINESE SCIENCE BULLETIN 53.8(2008):1121-1127.