Berberine promotes the development of atherosclerosis and foam cell formation by inducing scavenger receptor A expression in macrophage

	Berberine promotes the development of atherosclerosis and foam cell formation by inducing scavenger receptor A expression in macrophage
	Li, K; Yao, WQ; Zheng, XD; Liao, K
刊名	CELL RESEARCH
	2009
卷号	19 期号:8 页码:1006-1017
关键词	berberine scavenger receptor A macrophage foam cell atherosclerosis PI3-kinase-PTEN
通讯作者	Liao, K (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,kliao@sibs.ac.cn
英文摘要	Berberine is identified to lower the serum cholesterol level in human and hamster through the induction of low density lipoproteins (LDL) receptor in hepatic cells. To evaluate its potential in preventing atherosclerosis, the effect of berberine on atherosclerosis development in apolipoprotein E-deficient (apoE(-/-)) mice was investigated. In apoE(-/-) mice, berberine induced in vivo foam cell formation and promoted atherosclerosis development. The foam cell formation induced by berberine was also observed in mouse RAW264.7 cells, as well as in mouse and human primary macrophages. By inducing scavenger receptor A (SR-A) expression in macrophages, berberine increased the uptake of modified LDL (DiO-Ac-LDL). Berberine-induced SR-A expression was also observed in macrophage foam cells in vivo and in the cells at atherosclerotic lesion. Analysis in RAW264.7 cells indicated that berberine induced SR-A expression by suppressing PTEN expression, which led to sustained Akt activation. Our results suggest that to evaluate the potential of a cholesterol-reducing compound in alleviating atherosclerosis, its effect on the cells involved in atherosclerosis development, such as macrophages, should also be considered. Promotion of foam cell formation could counter-balance the beneficial effect of lowering serum cholesterol.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	LOW-DENSITY-LIPOPROTEIN ; 3T3-L1 ADIPOCYTE DIFFERENTIATION ; COLONY-STIMULATING FACTOR ; PPAR-GAMMA ; APOLIPOPROTEIN-E ; GENE-EXPRESSION ; DEFICIENT MICE ; OXIDIZED LDL ; CHOLESTEROL ; KINASE
收录类别	SCI
语种	英语
WOS记录号	WOS:000268722300011
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1225]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Li, K,Yao, WQ,Zheng, XD,et al. Berberine promotes the development of atherosclerosis and foam cell formation by inducing scavenger receptor A expression in macrophage[J]. CELL RESEARCH,2009,19(8):1006-1017.
APA	Li, K,Yao, WQ,Zheng, XD,&Liao, K.(2009).Berberine promotes the development of atherosclerosis and foam cell formation by inducing scavenger receptor A expression in macrophage.CELL RESEARCH,19(8),1006-1017.
MLA	Li, K,et al."Berberine promotes the development of atherosclerosis and foam cell formation by inducing scavenger receptor A expression in macrophage".CELL RESEARCH 19.8(2009):1006-1017.