Potent antitumor efficacy of interleukin-18 delivered by conditionally replicative adenovirus vector in renal cell carcinoma-bearing nude mice via inhibition of angiogenesis

	Potent antitumor efficacy of interleukin-18 delivered by conditionally replicative adenovirus vector in renal cell carcinoma-bearing nude mice via inhibition of angiogenesis
	Zheng, JN; Pei, DS; Sun, FH; Liu, XY; Mao, LJ; Zhang, BF; Wen, RM; Xu, W; Shi, Z; Liu, JJ
刊名	CANCER BIOLOGY & THERAPY
	2009
卷号	8 期号:7 页码:599-606
关键词	IL-18 oncolytic adenovirus VEGF CD34 renal cell carcinoma
通讯作者	Zheng, JN (reprint author), Affiliated Hosp Xuzhou Med Coll, Lab Urol, 99 W Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China.,jnzheng@xzmc.edu.cn
英文摘要	It has been demonstrated that interleukin 18 (IL-18) exerts antitumor activity. In this study, we investigated whether oncolytic adenovirus-mediated gene transfer of IL-18 could induce strong antitumor activity. A tumor-selective replicating adenovirus expressing IL-18 (ZD55-IL-18) was constructed by insertion of an IL-18 expression cassette into the ZD55 vector, which is based on deletion of the adenoviral E1B 55-kDa gene. ZD55-IL-18 could express substantially more IL-18 than Ad-IL-18 because of replication of the vector. It has been shown that ZD55-IL-18 exerted a strong cytopathic effect and significant apoptosis in renal cell carcinoma. ZD55-IL-18 significantly decreased VEGF and CD34 expression in the tumor cells. Treatment of established tumors with ZD55-IL-18 showed much stronger antitumor activity than that induced by ZD55-EGFP or Ad-IL-18. These data indicated that oncolytic adenovirus expressing IL-18 could exert potential antitumor activity via inhibition of angiogenesis and offer a novel approach to cancer therapy.
学科主题	Oncology
类目[WOS]	Oncology
关键词[WOS]	GAMMA INTERFERON-PRODUCTION ; FAS LIGAND ; IN-VIVO ; MELANOMA-CELLS ; EXPRESSION ; CANCER ; IL-18 ; THERAPY ; GROWTH ; GENE
收录类别	SCI
语种	英语
WOS记录号	WOS:000266248800013
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1221]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zheng, JN,Pei, DS,Sun, FH,et al. Potent antitumor efficacy of interleukin-18 delivered by conditionally replicative adenovirus vector in renal cell carcinoma-bearing nude mice via inhibition of angiogenesis[J]. CANCER BIOLOGY & THERAPY,2009,8(7):599-606.
APA	Zheng, JN.,Pei, DS.,Sun, FH.,Liu, XY.,Mao, LJ.,...&Li, W.(2009).Potent antitumor efficacy of interleukin-18 delivered by conditionally replicative adenovirus vector in renal cell carcinoma-bearing nude mice via inhibition of angiogenesis.CANCER BIOLOGY & THERAPY,8(7),599-606.
MLA	Zheng, JN,et al."Potent antitumor efficacy of interleukin-18 delivered by conditionally replicative adenovirus vector in renal cell carcinoma-bearing nude mice via inhibition of angiogenesis".CANCER BIOLOGY & THERAPY 8.7(2009):599-606.