Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts

	Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts
	Hou, YA; Wu, JC; Huang, Q; Guo, LH
刊名	CELL BIOLOGY INTERNATIONAL
	2009
卷号	33 期号:2 页码:135-147
关键词	Rheumatoid arthritis (RA) Synovial fibroblast (SFB) Luteolin Collagen-induced arthritis (CIA) Proliferation
通讯作者	Guo, LH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Room 901,Cell Biol Bldg,320 Yueyang Rd, Shanghai 200031, Peoples R China.,lhguo@sibs.ac.cn
英文摘要	Hyperproliferation of synovial fibroblasts is considered to be a pivotal event in the pathogenesis of rheumatoid arthritis (RA). Luteolin, a flavonoid, inhibits the proliferation of synovial fibroblasts in collagen-induced arthritic rats. Treatment with luteolin also decreases the secretion of matrix metalloprotease-1 and -3 and the expression of IL-6, IL-8, IL-15, and TGF-beta. Luteolin treatment caused a delay of cells in the G(2)/M phase. Interestingly, combination treatment with luteolin and TNF-alpha exhibited a synergistic inhibitory effect in all experiments. Western blotting demonstrated that treatment with luteolin alone or combined with TNF-alpha inhibited the MAPK/ERKs and PI3K-Akt pathways. These results indicate that luteolin inhibits the proliferation and partially blocks the pathogenic function of synovial fibroblasts in rheumatoid arthritis. (C) 2008 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	COLLAGEN-INDUCED ARTHRITIS ; TUMOR-NECROSIS-FACTOR ; CELL-CYCLE PROGRESSION ; RHEUMATOID-ARTHRITIS ; TNF-ALPHA ; SYNOVIOCYTES ; FLAVONOIDS ; APOPTOSIS ; EXPRESSION ; DISEASES
收录类别	SCI
语种	英语
WOS记录号	WOS:000262980300002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1149]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Hou, YA,Wu, JC,Huang, Q,et al. Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts[J]. CELL BIOLOGY INTERNATIONAL,2009,33(2):135-147.
APA	Hou, YA,Wu, JC,Huang, Q,&Guo, LH.(2009).Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts.CELL BIOLOGY INTERNATIONAL,33(2),135-147.
MLA	Hou, YA,et al."Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts".CELL BIOLOGY INTERNATIONAL 33.2(2009):135-147.