beta-Glucan Oligosaccharide Enhances CD8(+) TCells Immune Response Induced by a DNA Vaccine Encoding Hepatitis B Virus Core Antigen | |
Wang, J; Dong, SF; Liu, CH; Wang, W; Sun, SH; Gu, JX; Wang, YA; Boraschi, D; Qu, D | |
刊名 | JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY |
2010 | |
期号 | 1页码:645213-645213 |
通讯作者 | Qu, D (reprint author), Fudan Univ, Shanghai Med Coll, Inst Med Microbiol, Key Lab Med Mol Virol,Minist Educ & Hlth, Shanghai 200032, Peoples R China.,dqu@shmu.edu.cn |
英文摘要 | DNA vaccination can induce specific CD8(+) T cell immune response, but the response level is low in large mammals and human beings. Coadministration of an adjuvant can optimize protective immunity elicited by a DNA vaccine. In this study, we investigated the effect of a synthetic glucohexaose (beta-glu6), an analogue of Lentinan basic unit, on specific CD8(+) T cell response induced by a DNA vaccine encoding HBcAg (pB144) in mice. We found that beta-glu6 promoted the recruitment and maturation of dendritic cells, enhanced the activation of CD8(+) and CD4(+) T cells and increased the number of specific CD8(+)/IFN-gamma(+) T cells in lymphoid and nonlymphoid tissues in mice immunized by pB144. Immunization with pB144 and beta-glu6 increased the anti-HBc IgG and IgG2a antibody titer. These results demonstrate that beta-glu6 can enhance the virus-specific CTL and Th1 responses induced by DNA vaccine, suggesting beta-glu6 as a candidate adjuvant in DNA vaccination. |
学科主题 | Biotechnology & Applied Microbiology; Research & Experimental Medicine |
类目[WOS] | Biotechnology & Applied Microbiology ; Medicine, Research & Experimental |
关键词[WOS] | DENDRITIC CELLS ; T-CELLS ; ANTITUMOR-ACTIVITY ; LENTINAN ; IMMUNIZATION ; PROTEIN ; GENE ; BOND ; POLYSACCHARIDE ; COIMMUNIZATION |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000279791900001 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/1108] |
专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
推荐引用方式 GB/T 7714 | Wang, J,Dong, SF,Liu, CH,et al. beta-Glucan Oligosaccharide Enhances CD8(+) TCells Immune Response Induced by a DNA Vaccine Encoding Hepatitis B Virus Core Antigen[J]. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY,2010(1):645213-645213. |
APA | Wang, J.,Dong, SF.,Liu, CH.,Wang, W.,Sun, SH.,...&Qu, D.(2010).beta-Glucan Oligosaccharide Enhances CD8(+) TCells Immune Response Induced by a DNA Vaccine Encoding Hepatitis B Virus Core Antigen.JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY(1),645213-645213. |
MLA | Wang, J,et al."beta-Glucan Oligosaccharide Enhances CD8(+) TCells Immune Response Induced by a DNA Vaccine Encoding Hepatitis B Virus Core Antigen".JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY .1(2010):645213-645213. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论