Important aspects of Toll-like receptors, ligands and their signaling pathways

	Important aspects of Toll-like receptors, ligands and their signaling pathways
	Chang, ZL
刊名	INFLAMMATION RESEARCH
	2010
卷号	59 期号:10 页码:791-808
关键词	TLRs Ligands Cell signaling Inflammation
通讯作者	Chang, ZL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,chang_zong_liang@hotmail.com
英文摘要	Due to the rapid increase of new information on the multiple roles of Toll-like receptors (TLRs), this paper reviews several main properties of TLRs and their ligands and signaling pathways. The investigation of pathogen infections in knockout mice suggests that specific TLRs play a key role in the activation of immune responses. Although the investigation of TLR biology is just beginning, a number of important findings are emerging. This review focuses on the following seven aspects of this emerging field: (a) a history of TLR and ligand studies; (b) the molecular basis of recognition by TLRs: TLR structures, pathogen-associated molecular pattern binding sites, TLR locations and functional responses; (c) cell types in TLR expression; (d) an overview of TLRs and their ligands: expression and ligands of cell-surface TLRs and of intracellular TLRs; (e) TLR-signaling pathways; (f) discussion: TLRs control of innate and adaptive systems; the trafficking of intracellular TLRs to endolysosomes; investigation of TLRs in regulating microRNA; investigation of crystal structure of TLRs with ligand binding; incidence of infectious diseases associated with single nucleotide polymorphisms (SNPs) in TLR genes; risk of cancer related to SNPs in TLR genes; TLR-ligand mediated anti-cancer effects; and TLR-ligand induced chronic inflammation and tumorigenesis; and (g) conclusions.
学科主题	Cell Biology; Immunology
类目[WOS]	Cell Biology ; Immunology
关键词[WOS]	NF-KAPPA-B ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; TUMOR-ASSOCIATED MACROPHAGES ; URINARY-TRACT-INFECTION ; LEUCINE-RICH REPEATS ; PROSTATE-CANCER RISK ; DOUBLE-STRANDED-RNA ; REGULATORY T-CELLS ; DOUBLE-EDGED-SWORD ; CUTTING EDGE
收录类别	SCI
语种	英语
WOS记录号	WOS:000281669400001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1058]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chang, ZL. Important aspects of Toll-like receptors, ligands and their signaling pathways[J]. INFLAMMATION RESEARCH,2010,59(10):791-808.
APA	Chang, ZL.(2010).Important aspects of Toll-like receptors, ligands and their signaling pathways.INFLAMMATION RESEARCH,59(10),791-808.
MLA	Chang, ZL."Important aspects of Toll-like receptors, ligands and their signaling pathways".INFLAMMATION RESEARCH 59.10(2010):791-808.