Recent Transcription-induced Histone H3 Lysine 4 (H3K4) Methylation Inhibits Gene Reactivation

	Recent Transcription-induced Histone H3 Lysine 4 (H3K4) Methylation Inhibits Gene Reactivation
	Zhou, BO; Zhou, JQ
刊名	JOURNAL OF BIOLOGICAL CHEMISTRY
	2011
卷号	286 期号:40 页码:34770-34776
通讯作者	Zhou, JQ (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci,Grad Sch, Shanghai 200031, Peoples R China.,jqzhou@sibs.ac.cn
英文摘要	Recent transcription of GAL genes transiently leaves an H3K4 methylation mark at their promoters, providing an epigenetic memory for the recent transcriptional activity. However, the physiological significance of this mark is enigmatic. In our study, we show that the transient H3K4di- and trimethylation at recently transcribed GAL1 inhibited the reinduction of GAL1. The H3K4 methylation functioned by recruiting the Isw1 ATPase onto GAL1 and thereby limiting the action of RNA polymerase II during GAL1 reactivation. Strikingly, the H3K4 methylation was also observed at the promoters of inositol- and fatty acid-responsive genes after recent transcription and played a negative role in their reinduction. Taken together, our data present a new mechanism by which H3K4 methylation regulates gene transcription.
学科主题	Biochemistry & Molecular Biology
类目[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	SACCHAROMYCES-CEREVISIAE ; CHROMATIN MODIFICATIONS ; S. CEREVISIAE ; YEAST ; MEMORY ; UBIQUITINATION ; COMPLEX ; SET1 ; ACTIVATION ; EXPRESSION
收录类别	SCI
语种	英语
WOS记录号	WOS:000295406300031
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/890]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhou, BO,Zhou, JQ. Recent Transcription-induced Histone H3 Lysine 4 (H3K4) Methylation Inhibits Gene Reactivation[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2011,286(40):34770-34776.
APA	Zhou, BO,&Zhou, JQ.(2011).Recent Transcription-induced Histone H3 Lysine 4 (H3K4) Methylation Inhibits Gene Reactivation.JOURNAL OF BIOLOGICAL CHEMISTRY,286(40),34770-34776.
MLA	Zhou, BO,et al."Recent Transcription-induced Histone H3 Lysine 4 (H3K4) Methylation Inhibits Gene Reactivation".JOURNAL OF BIOLOGICAL CHEMISTRY 286.40(2011):34770-34776.