Genome-scale study of transcription factor expression in the branching mouse lung

	Genome-scale study of transcription factor expression in the branching mouse lung
	Herriges, JC; Yi, L; Hines, EA; Harvey, JF; Xu, GL; Gray, PA; Ma, QF; Sun, X
刊名	DEVELOPMENTAL DYNAMICS
	2012
卷号	241 期号:9 页码:1432-1453
关键词	lung mouse transcription factors expression patterns branching
通讯作者	Sun, X (reprint author), Univ Wisconsin, Genet Lab, Madison, WI 53706 USA.,xsun@wisc.edu
英文摘要	Background: Mammalian lung development consists of a series of precisely choreographed events that drive the progression from simple lung buds to the elaborately branched organ that fulfills the vital function of gas exchange. Strict transcriptional control is essential for lung development. Among the large number of transcription factors encoded in the mouse genome, only a small portion of them are known to be expressed and function in the developing lung. Thus a systematic investigation of transcription factors expressed in the lung is warranted. Results: To enrich for genes that may be responsible for regional growth and patterning, we performed a screen using RNA in situ hybridization to identify genes that show restricted expression patterns in the embryonic lung. We focused on the pseudoglandular stage during which the lung underergoes branching morphogenesis, a cardinal event of lung development. Using a genome-scale probe set that represents over 90% of the transcription factors encoded in the mouse genome, we identified 62 transcription factor genes with localized expression in the epithelium, mesenchyme, or both. Many of these genes have not been previously implicated in lung development. Conclusions: Our findings provide new starting points for the elucidation of the transcriptional circuitry that controls lung development. Developmental Dynamics 241:1432-1453, 2012. (c) 2012 Wiley Periodicals, Inc.
学科主题	Anatomy & Morphology; Developmental Biology
类目[WOS]	Anatomy & Morphology ; Developmental Biology
关键词[WOS]	ENDOPLASMIC-RETICULUM STRESS ; EPITHELIAL-MESENCHYMAL INTERACTIONS ; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA ; EXTRACELLULAR-MATRIX PRODUCTION ; CHROMATIN REMODELING COMPLEXES ; MORPHOGENETIC PROTEIN-4 BMP-4 ; OBSTRUCTIVE PULMONARY-DISEASE ; POLYCYSTIC KIDNEY-DISEASE ; IROQUOIS HOMEOBOX GENES ; VASCULAR SMOOTH-MUSCLE
收录类别	SCI
语种	英语
WOS记录号	WOS:000307882200006
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/641]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Herriges, JC,Yi, L,Hines, EA,et al. Genome-scale study of transcription factor expression in the branching mouse lung[J]. DEVELOPMENTAL DYNAMICS,2012,241(9):1432-1453.
APA	Herriges, JC.,Yi, L.,Hines, EA.,Harvey, JF.,Xu, GL.,...&Sun, X.(2012).Genome-scale study of transcription factor expression in the branching mouse lung.DEVELOPMENTAL DYNAMICS,241(9),1432-1453.
MLA	Herriges, JC,et al."Genome-scale study of transcription factor expression in the branching mouse lung".DEVELOPMENTAL DYNAMICS 241.9(2012):1432-1453.