Niemann-Pick C1-Like 1 and cholesterol uptake

	Niemann-Pick C1-Like 1 and cholesterol uptake
	Wang, LJ; Song, BL
刊名	BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
	2012
卷号	1821 期号:7 页码:964-972
关键词	NPC1L1 Cholesterol absorption Ezetimibe NPC1 Flotillin Lipid raft
通讯作者	Song, BL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,blsong@sibs.ac.cn
英文摘要	Niemann-Pick Cl-Like 1 (NPC1L1) is a polytopic transmembrane protein responsible for dietary cholesterol and biliary cholesterol absorption. Consistent with its functions. NPC1L1 distributes on the brush border membrane of enterocytes and the canalicular membrane of hepatocytes in humans. As the molecular target of ezetimibe, a hypocholesterolemic drug, its physiological and pathological significance has been recognized and intensively studied for years. Recently, plenty of new findings reveal the molecular mechanism of NPC1L1's role in cholesterol uptake, which may provide new insights on our understanding of cholesterol absorption. In this review, we summarized recent progress in these studies and proposed a working model, hoping to provide new perspectives on the regulation of cholesterol transport and metabolism. (C) 2012 Elsevier B.V. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Biophysics; Cell Biology
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]	ENDOCYTIC RECYCLING COMPARTMENT ; ABSORPTION INHIBITOR EZETIMIBE ; STEROL-SENSING DOMAIN ; TRANS-GOLGI NETWORK ; N-TERMINAL DOMAIN ; DIETARY-CHOLESTEROL ; C1 PROTEIN ; PRIMARY HYPERCHOLESTEROLEMIA ; GENETIC-VARIATION ; PLASMA-MEMBRANE
收录类别	SCI
语种	英语
WOS记录号	WOS:000305359200003
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/622]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wang, LJ,Song, BL. Niemann-Pick C1-Like 1 and cholesterol uptake[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,2012,1821(7):964-972.
APA	Wang, LJ,&Song, BL.(2012).Niemann-Pick C1-Like 1 and cholesterol uptake.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,1821(7),964-972.
MLA	Wang, LJ,et al."Niemann-Pick C1-Like 1 and cholesterol uptake".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1821.7(2012):964-972.