Recombinatorial Biases and Convergent Recombination Determine Interindividual TCR beta Sharing in Murine Thymocytes

	Recombinatorial Biases and Convergent Recombination Determine Interindividual TCR beta Sharing in Murine Thymocytes
	Li, HJ; Ye, CT; Ji, GL; Wu, XH; Xiang, Z; Li, YY; Cao, YH; Liu, XL; Douek, DC; Price, DA
刊名	JOURNAL OF IMMUNOLOGY
	2012
卷号	189 期号:5 页码:2404-2413
通讯作者	Han, JH (reprint author), Xiamen Univ, State Key Lab Cellular Stress Biol, Xiamen 361005, Fujian, Peoples R China.,glji@xmu.edu.cn ; dprice1@mail.nih.gov ; jhan@xmu.edu.cn
英文摘要	Overlap of TCR repertoires among individuals provides the molecular basis for public T cell responses. By deep-sequencing the TCR beta repertoires of CD4(+)CD8(+) thymocytes from three individual mice, we observed that a substantial degree of TCR beta overlap, comprising similar to 10-15% of all unique amino acid sequences and similar to 5-10% of all unique nucleotide sequences across any two individuals, is already present at this early stage of T cell development. The majority of TCR beta sharing between individual thymocyte repertoires could be attributed to the process of convergent recombination, with additional contributions likely arising from recombinatorial biases; the role of selection during intrathymic development was negligible. These results indicate that the process of TCR gene recombination is the major determinant of clonotype sharing between individuals. The Journal of Immunology, 2012, 189: 2404-2413.
学科主题	Immunology
类目[WOS]	Immunology
关键词[WOS]	T-CELL REPERTOIRE ; V(D)J RECOMBINATION ; POSITIVE SELECTION ; RECEPTOR BIAS ; DIVERSITY ; RESPONSES ; IMMUNITY ; USAGE ; CDR3
收录类别	SCI
语种	英语
WOS记录号	WOS:000308083600040
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/591]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Li, HJ,Ye, CT,Ji, GL,et al. Recombinatorial Biases and Convergent Recombination Determine Interindividual TCR beta Sharing in Murine Thymocytes[J]. JOURNAL OF IMMUNOLOGY,2012,189(5):2404-2413.
APA	Li, HJ.,Ye, CT.,Ji, GL.,Wu, XH.,Xiang, Z.,...&Han, JH.(2012).Recombinatorial Biases and Convergent Recombination Determine Interindividual TCR beta Sharing in Murine Thymocytes.JOURNAL OF IMMUNOLOGY,189(5),2404-2413.
MLA	Li, HJ,et al."Recombinatorial Biases and Convergent Recombination Determine Interindividual TCR beta Sharing in Murine Thymocytes".JOURNAL OF IMMUNOLOGY 189.5(2012):2404-2413.