Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA

	Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA
	Zhang, L; Lu, XY; Lu, JY; Liang, HH; Dai, Q; Xu, GL; Luo, C; Jiang, HL; He, C
刊名	NATURE CHEMICAL BIOLOGY
	2012
卷号	8 期号:4 页码:328-330
通讯作者	Zhang, L (reprint author), Univ Chicago, Dept Chem, 5735 S Ellis Ave, Chicago, IL 60637 USA.,chuanhe@uchicago.edu
英文摘要	Human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC), a key oxidation product of 5-methylcytosine in genomic DNA, in a recently discovered cytosine demethylation pathway. We present here the crystal structures of the hTDG catalytic domain in complex with duplex DNA containing either 5caC or a fluorinated analog. These structures, together with biochemical and computational analyses, reveal that 5caC is specifically recognized in the active site of hTDG, supporting the role of TDG in mammalian 5-methylcytosine demethylation.
学科主题	Biochemistry & Molecular Biology
类目[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	BASE EXCISION-REPAIR ; MAMMALIAN DNA ; TET PROTEINS ; DEMETHYLATION ; 5-FORMYLCYTOSINE ; 5-METHYLCYTOSINE ; SUBSTRATE ; CONVERSION ; CHEMISTRY ; CPG
收录类别	SCI
语种	英语
WOS记录号	WOS:000301890100005
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/583]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhang, L,Lu, XY,Lu, JY,et al. Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA[J]. NATURE CHEMICAL BIOLOGY,2012,8(4):328-330.
APA	Zhang, L.,Lu, XY.,Lu, JY.,Liang, HH.,Dai, Q.,...&He, C.(2012).Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.NATURE CHEMICAL BIOLOGY,8(4),328-330.
MLA	Zhang, L,et al."Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA".NATURE CHEMICAL BIOLOGY 8.4(2012):328-330.