Reversion of the ErbB malignant phenotype and the DNA damage response

	Reversion of the ErbB malignant phenotype and the DNA damage response
	Runkle, EA; Zhang, HT; Cai, Z; Zhu, ZG; Karger, BL; Wu, SL; O'Rourke, DM; Zhou, ZC; Wang, Q; Greene, MI
刊名	EXPERIMENTAL AND MOLECULAR PATHOLOGY
	2012
卷号	93 期号:3 页码:324-333
关键词	HER ErbB EGFR DNA repair Double-strand breaks Ionizing radiation Nuclear compartmentalization SUN KASH LINC
通讯作者	Greene, MI (reprint author), Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.,greene@reo.med.upenn.edu
英文摘要	The ErbB or HER family is a group of membrane bound tyrosine kinase receptors that initiate signal transduction cascades, which are critical to a wide range of biological processes. When over-expressed or mutated, members of this kinase family form homomeric or heteromeric kinase assemblies that are involved in certain human malignancies. Targeted therapy evolved from studies showing that monoclonal antibodies to the ectodomain of ErbB2/neu would reverse the malignant phenotype. Unfortunately, tumors develop resistance to targeted therapies even when coupled with genotoxic insults such as radiation. Radiation treatment predominantly induces double strand DNA breaks, which, if not repaired, are potentially lethal to the cell. Some tumors are resistant to radiation treatment because they effectively repair double strand breaks. We and others have shown that even in the presence of ionizing radiation, active ErbB kinase signaling apparently enhances the repair process, such that transformed cells resist genotoxic signal induced cell death. We review here the current understanding of ErbB signaling and DNA double strand break repair. Some studies have identified a mechanism by which DNA damage is coordinated to assemblies of proteins that associate with SUN domain containing proteins. These assemblies represent a new target for therapy of resistant tumor cells. (C) 2012 Elsevier Inc. All rights reserved.
学科主题	Pathology
类目[WOS]	Pathology
关键词[WOS]	DEPENDENT PROTEIN-KINASE ; EPIDERMAL-GROWTH-FACTOR ; DOUBLE-STRAND BREAK ; SQUAMOUS-CELL CARCINOMA ; SPINDLE POLE BODY ; XRCC4-DNA LIGASE-IV ; HUMAN TUMOR-CELLS ; PHASE-I/II TRIAL ; FACTOR RECEPTOR ; CATALYTIC SUBUNIT
收录类别	SCI
语种	英语
WOS记录号	WOS:000312466100009
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/555]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Runkle, EA,Zhang, HT,Cai, Z,et al. Reversion of the ErbB malignant phenotype and the DNA damage response[J]. EXPERIMENTAL AND MOLECULAR PATHOLOGY,2012,93(3):324-333.
APA	Runkle, EA.,Zhang, HT.,Cai, Z.,Zhu, ZG.,Karger, BL.,...&Greene, MI.(2012).Reversion of the ErbB malignant phenotype and the DNA damage response.EXPERIMENTAL AND MOLECULAR PATHOLOGY,93(3),324-333.
MLA	Runkle, EA,et al."Reversion of the ErbB malignant phenotype and the DNA damage response".EXPERIMENTAL AND MOLECULAR PATHOLOGY 93.3(2012):324-333.