Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum

	Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum
	Kong, LW; Choi, RCY; Tsim, KWK; Jing, NH; Nakayama, DK; Wang, ZB
刊名	NEUROSCIENCE LETTERS
	2013
卷号	543 期号:1 页码:22-26
关键词	rKirre IgSF CAM Cerebellum Granule cell Purkinje cell Development
通讯作者	Wang, ZB (reprint author), Mercer Univ, Sch Med, Dept Surg, 1550 Coll St, Macon, GA 31207 USA.,wang_z@mercer.edu
英文摘要	Immunoglobulin superfamily (IgSF) molecules are actively involved in cell-cell adhesion, neuronal migration, axonal guidance and synapse formation in the nervous system. Kirre, as a member of this family, has been implicated in mammalian neuronal differentiation and development. Although the distribution of rKirre (a rat homologue of Drosophila Kirre) mRNA was previously analyzed in adult rat cerebellum by in situ hybridization, the expression levels of transcript and protein were not well studied. Here, we showed that the expressions of rKirre mRNA and protein significantly increased during postnatal development of rat cerebellum. rKirre mRNA was mainly expressed in the granular layers and Purkinje cell layer in the developing cerebellum, revealing a possible involvement of rKirre in granule cell migration and Purkinje cell development. An essential relationship between rKirre and Purkinje cells was implied by the co-localization of rKirre and NF-200 on the cell bodies of Purkinje cells. These results suggest that rKirre may play a potential role in postnatal developing rat cerebellum. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	RECEPTOR TYROSINE KINASE ; CELL-ADHESION MOLECULES ; IMMUNOGLOBULIN SUPERFAMILY ; MYOBLAST FUSION ; DROSOPHILA-MELANOGASTER ; CONTACTIN/F3 SUBGROUP ; PURKINJE-CELLS ; MOUSE-BRAIN ; NEPHRIN ; PROTEIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000319646000005
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/516]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Kong, LW,Choi, RCY,Tsim, KWK,et al. Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum[J]. NEUROSCIENCE LETTERS,2013,543(1):22-26.
APA	Kong, LW,Choi, RCY,Tsim, KWK,Jing, NH,Nakayama, DK,&Wang, ZB.(2013).Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum.NEUROSCIENCE LETTERS,543(1),22-26.
MLA	Kong, LW,et al."Distribution and expression of Kirre, an IgSF molecule, during postnatal development of rat cerebellum".NEUROSCIENCE LETTERS 543.1(2013):22-26.