Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis with impaired T(H)17 cell differentiation

	Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis with impaired T(H)17 cell differentiation
	Li, J; Wei, B; Guo, A; Liu, C; Huang, SC; Du, F; Fan, W; Bao, CD; Pei, G
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2013
卷号	110 期号:18 页码:7395-7400
通讯作者	Pei, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol,Grad Sch, Shanghai 200031, Peoples R China.,gpei@sibs.ac.cn
英文摘要	Rheumatoid arthritis (RA) is an inflammatory disease in which interleukin 17 (IL-17)-producing T helper 17 (T(H)17) cells have been critically involved. We show that in patients with RA, the expression of a multifunctional regulator beta-arrestin1 was significantly up-regulated in peripheral and synovial CD4(+) T cells, which correlated well with active phases of RA. In collagen-induced arthritis, deficiency of beta-arrestin1 ameliorated disease with decreased T(H)17 cell differentiation, proinflammatory cytokine production, synovitis, and cartilage and bone destruction. Further mechanistic study reveals that beta-arrestin1 promoted signal transducer and activator of transcription 3 (STAT3) activation required for T(H)17 cell differentiation through scaffolding the interaction of Janus kinase 1 and STAT3. These findings indicate a critical role for beta-arrestin1 in the pathogenesis of collagen-induced arthritis and T(H)17 cell differentiation and suggest beta-arrestin1 as a potential diagnostic biomarker and therapeutic target for RA.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	HELPER T-CELLS ; RHEUMATOID-ARTHRITIS ; BETA-ARRESTINS ; TH17 CELLS ; STAT3 ; MICE ; INFLAMMATION ; DISEASE ; GENERATION ; INDUCTION
收录类别	SCI
语种	英语
WOS记录号	WOS:000318682300062
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/460]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Li, J,Wei, B,Guo, A,et al. Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis with impaired T(H)17 cell differentiation[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2013,110(18):7395-7400.
APA	Li, J.,Wei, B.,Guo, A.,Liu, C.,Huang, SC.,...&Pei, G.(2013).Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis with impaired T(H)17 cell differentiation.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,110(18),7395-7400.
MLA	Li, J,et al."Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis with impaired T(H)17 cell differentiation".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110.18(2013):7395-7400.