SREBP: a novel therapeutic target

	SREBP: a novel therapeutic target
	Xiao, X; Song, BL
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2013
卷号	45 期号:1 页码:42045
关键词	SREBP insulin cAMP vitamin A miRNA therapeutic target
通讯作者	Xiao, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,xiaoxu@sibcb.ac.cn
英文摘要	Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the biosynthesis of cholesterol, fatty acid, and triglyceride. They control the expression of crucial genes involved in lipogenesis and uptake. In this review, we summarize the processing of SREBPs and their regulation by insulin, cAMP, and vitamin A, and the relationship between miRNA and lipid metabolism. We also discuss the recent functional studies on SREBPs. These discoveries suggest that inhibition of SREBP can be a novel strategy to treat metabolic diseases, such as type II diabetes, insulin resistance, fatty liver, and atherosclerosis.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	ELEMENT-BINDING PROTEIN-1C ; HMG-COA REDUCTASE ; LIVER-X-RECEPTOR ; FATTY-ACID SYNTHESIS ; NECROSIS-FACTOR-ALPHA ; CHOLESTEROL HOMEOSTASIS ; ENDOPLASMIC-RETICULUM ; INSULIN-RESISTANCE ; LIPID-METABOLISM ; COPII PROTEINS
收录类别	SCI
语种	英语
WOS记录号	WOS:000312640100002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/328]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Xiao, X,Song, BL. SREBP: a novel therapeutic target[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2013,45(1):42045.
APA	Xiao, X,&Song, BL.(2013).SREBP: a novel therapeutic target.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,45(1),42045.
MLA	Xiao, X,et al."SREBP: a novel therapeutic target".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 45.1(2013):42045.