Integrative Genomic Analysis Reveals a High Frequency of LKB1 Genetic Alteration in Chinese Lung Adenocarcinomas

	Integrative Genomic Analysis Reveals a High Frequency of LKB1 Genetic Alteration in Chinese Lung Adenocarcinomas
	Fang, R; Zheng, C; Sun, YH; Han, XK; Gao, B; Li, CG; Liu, HY; Wong, KK; Liu, XY; Chen, HQ
刊名	JOURNAL OF THORACIC ONCOLOGY
	2014
卷号	9 期号:2 页码:254-258
关键词	Liver kinase B1 Lung cancer Multiplex ligation-dependent probe amplification
通讯作者	Ji, HB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China.,hbji@sibcb.ac.cn
英文摘要	Liver kinase B1 (LKB1) genetic alteration in lung cancer involves not only point mutations and small deletion of several base pairs but also exonic loss. However, most of recent studies in LKB1 gene status only focus on point mutations and small deletion, and thus may underestimate the actual frequency of LKB1 genetic alteration in lung cancer. Thus, an integrative analysis of LKB1 genetic alteration is timely and important for providing a better estimate for the incidence of genetic alterations in this important tumor suppressor gene. One hundred and seven lung adenocarcinomas with more than 70% tumor have been analyzed for mutation of LKB1 as well as LKB1 large deletions detection by using multiplex ligation-dependent probe amplification analysis. These samples were also analyzed for EGFR, KRAS, HER2, BRAF, ALK, ROS1, and RET status in stepwise method. Among 107 lung adenocarcinomas analyzed, 29 (27.1%) harbored LKB1 genetic alteration. Twenty-three (21.5%) harbored LKB1 large exonic deletions and eight (7.48%) had LKB1 points mutations, two samples harbored both LKB1 large exonic deletions and point mutations. Eighty-seven samples (81.31%) harbored known driver mutations and 20 samples (18.69%) had no identifiable driver mutations. A high rate of LKB1 genetic alteration in Chinese lung adenocarcinomas is revealed by the integrative analysis of point mutation and exonic deletion. Moreover, LKB1 genetic alterations are concurrent with EGFR, KRAS, HER2, and CD74-ROS fusions.
学科主题	Oncology ; Respiratory System
类目[WOS]	Oncology ; Respiratory System
关键词[WOS]	PEUTZ-JEGHERS-SYNDROME ; CANCER PATIENTS ; MUTATIONS ; SPECTRUM ; LKB1/STK11
收录类别	SCI
语种	英语
WOS记录号	WOS:000330078100024
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/149]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Fang, R,Zheng, C,Sun, YH,et al. Integrative Genomic Analysis Reveals a High Frequency of LKB1 Genetic Alteration in Chinese Lung Adenocarcinomas[J]. JOURNAL OF THORACIC ONCOLOGY,2014,9(2):254-258.
APA	Fang, R.,Zheng, C.,Sun, YH.,Han, XK.,Gao, B.,...&Ji, HB.(2014).Integrative Genomic Analysis Reveals a High Frequency of LKB1 Genetic Alteration in Chinese Lung Adenocarcinomas.JOURNAL OF THORACIC ONCOLOGY,9(2),254-258.
MLA	Fang, R,et al."Integrative Genomic Analysis Reveals a High Frequency of LKB1 Genetic Alteration in Chinese Lung Adenocarcinomas".JOURNAL OF THORACIC ONCOLOGY 9.2(2014):254-258.