Comparative Investigation of Human Amniotic Epithelial Cells and Mesenchymal Stem Cells for Application in Bone Tissue Engineering

	Comparative Investigation of Human Amniotic Epithelial Cells and Mesenchymal Stem Cells for Application in Bone Tissue Engineering
	Si, JW; Dai, JW; Zhang, JJ; Liu, S; Gu, J; Shi, J; Shen, SGF; Guo, LH
刊名	STEM CELLS INTERNATIONAL
	2015
期号	1 页码:565732-565732
通讯作者	Shen, SGF (reprint author), Shanghai Jiao Tong Univ, Peoples Hosp 9, Coll Stomatol, Sch Med,Dept Oral & Craniomaxillofacial Sci,Shang, Shanghai 200011, Peoples R China.,maxillofacsurg@163.com ; 253541933@qq.com
英文摘要	Emerging evidence suggests amniotic epithelial cells (AECs) as a promising source of progenitor cells in regenerative medicine and bone tissue engineering. However, investigations comparing the regenerative properties of AECs with other sources of stem cells are particularly needed before the feasibility of AECs in bone tissue engineering can be determined. This study aimed to compare human amniotic epithelial cells (hAECs), human bone marrow mesenchymal stem cells (hBMSCs), and human amniotic fluid derived mesenchymal stem cells (hAFMSCs) in terms of their morphology, proliferation, immunophenotype profile, and osteogenic capacity in vitro and in vivo. Not only greatly distinguished by cellmorphology and proliferation, hAECs, hAFMSCs, and hBMSCs exhibited remarkably different signature regarding immunophenotypical profile. Microarray analysis revealed a different expression profile of genes involved in ossification along the three cell sources, highlighting the impact of different anatomical origin and molecular response to osteogenic induction on the final tissue-forming potential. Furthermore, our data indicated a potential role of FOXC2 in early osteogenic commitment.
学科主题	Cell Biology
类目[WOS]	Cell & Tissue Engineering
关键词[WOS]	IN-VITRO ; OSTEOGENIC DIFFERENTIATION ; PERIODONTAL-LIGAMENT ; ADIPOSE-TISSUE ; STROMAL CELLS ; REGENERATION ; FLUID ; PLURIPOTENT ; EXPRESSION ; VIVO
收录类别	SCI
语种	英语
WOS记录号	WOS:000351368900001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/113]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Si, JW,Dai, JW,Zhang, JJ,et al. Comparative Investigation of Human Amniotic Epithelial Cells and Mesenchymal Stem Cells for Application in Bone Tissue Engineering[J]. STEM CELLS INTERNATIONAL,2015(1):565732-565732.
APA	Si, JW.,Dai, JW.,Zhang, JJ.,Liu, S.,Gu, J.,...&Guo, LH.(2015).Comparative Investigation of Human Amniotic Epithelial Cells and Mesenchymal Stem Cells for Application in Bone Tissue Engineering.STEM CELLS INTERNATIONAL(1),565732-565732.
MLA	Si, JW,et al."Comparative Investigation of Human Amniotic Epithelial Cells and Mesenchymal Stem Cells for Application in Bone Tissue Engineering".STEM CELLS INTERNATIONAL .1(2015):565732-565732.