Regulation of circRNA biogenesis

	Regulation of circRNA biogenesis
	Chen, LL; Yang, L
刊名	RNA BIOLOGY
	2015
卷号	12 期号:4 页码:381-388
关键词	alternative circularization back-splicing circularization circular RNA complementary sequence splicing
通讯作者	Chen, LL (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China.,linglingchen@sibcb.ac.cn ; liyang@picb.ac.cn
英文摘要	Unlike linear RNAs terminated with 5 caps and 3 tails, circular RNAs are characterized by covalently closed loop structures with neither 5 to 3 polarity nor polyadenylated tail. This intrinsic characteristic has led to the general under-estimation of the existence of circular RNAs in previous polyadenylated transcriptome analyses. With the advent of specific biochemical and computational approaches, a large number of circular RNAs from back-spliced exons (circRNAs) have been identified in various cell lines and across different species. Recent studies have uncovered that back-splicing requires canonical spliceosomal machinery and can be facilitated by both complementary sequences and specific protein factors. In this review, we highlight our current understanding of the regulation of circRNA biogenesis, including both the competition between splicing and back-splicing and the previously under-appreciated alternative circularization.
学科主题	Biochemistry & Molecular Biology
类目[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	CIRCULAR RNA MOLECULES ; EXON CIRCULARIZATION ; HUMAN TRANSCRIPTOME ; MESSENGER-RNAS ; INTRONS ; REVEALS ; PROTEINS ; REPEATS ; VIROIDS ; BIOLOGY
收录类别	SCI
语种	英语
WOS记录号	WOS:000352654300003
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/53]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chen, LL,Yang, L. Regulation of circRNA biogenesis[J]. RNA BIOLOGY,2015,12(4):381-388.
APA	Chen, LL,&Yang, L.(2015).Regulation of circRNA biogenesis.RNA BIOLOGY,12(4),381-388.
MLA	Chen, LL,et al."Regulation of circRNA biogenesis".RNA BIOLOGY 12.4(2015):381-388.