The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6

	The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6
	Jiao, S; Zhang, Z; Li, CC; Huang, M; Shi, ZB; Wang, YY; Song, XM; Liu, H; Li, CY; Chen, M
刊名	NATURE IMMUNOLOGY
	2015
卷号	16 期号:3 页码:246-U204
通讯作者	Zhou, ZC (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Natl Ctr Prot Sci Shanghai, State Key Lab Cell Biol,Inst Biochem & Cell Biol, Shanghai, Peoples R China.,cwang01@sibcb.ac.cn ; zczhou@sibcb.ac.cn
英文摘要	Immune responses need to be tightly controlled to avoid excessive inflammation and prevent unwanted host damage. Here we report that germinal center kinase MST4 responded dynamically to bacterial infection and acted as a negative regulator of inflammation. We found that MST4 directly interacted with and phosphorylated the adaptor TRAF6 to prevent its oligomerization and autoubiquitination. Accordingly, MST4 did not inhibit lipopolysaccharide-induced cytokine production in Traf6(-/-) embryonic fibroblasts transfected to express a mutant form of TRAF6 that cannot be phosphorylated at positions 463 and 486 ( with substitution of alanine for threonine at those positions). Upon developing septic shock, mice in which MST4 was knocked down showed exacerbated inflammation and reduced survival, whereas heterozygous deletion of Traf6 (Traf6(+/-)) alleviated such deleterious effects. Our findings reveal a mechanism by which TRAF6 is regulated and highlight a role for MST4 in limiting inflammatory responses.
学科主题	Immunology
类目[WOS]	Immunology
关键词[WOS]	NF-KAPPA-B ; STE20-RELATED KINASE ; PROVIDES INSIGHTS ; CELL-GROWTH ; I RECEPTOR ; ACTIVATION ; COMPLEX ; UBIQUITINATION ; MECHANISM ; CANCER
收录类别	SCI
语种	英语
WOS记录号	WOS:000349842100008
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/39]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Jiao, S,Zhang, Z,Li, CC,et al. The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6[J]. NATURE IMMUNOLOGY,2015,16(3):246-U204.
APA	Jiao, S.,Zhang, Z.,Li, CC.,Huang, M.,Shi, ZB.,...&Zhou, ZC.(2015).The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6.NATURE IMMUNOLOGY,16(3),246-U204.
MLA	Jiao, S,et al."The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6".NATURE IMMUNOLOGY 16.3(2015):246-U204.