Decoding Ci: From partial degradation to inhibition

	Decoding Ci: From partial degradation to inhibition
	Xiong, Y; Liu, CY; Zhao, Y
刊名	DEVELOPMENT GROWTH & DIFFERENTIATION
	2015
卷号	57 期号:2 页码:98-108
关键词	cubitus interruptus degradation feedback regulation Hedgehog signaling phosphorylation ubiquitination
通讯作者	Zhao, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,yunzhao@sibcb.ac.cn
英文摘要	Hedgehog is a morphogen, which is widely involved in the regulation of cell proliferation, differentiation and tissue patterning during development in both vertebrate and invertebrate, such as in coordination of eye, brain, gonad, gut and tracheal development. In invertebrate, Cubitus interruptus (Ci) modification process is the last identified step before transcriptional activation in the Hh signaling pathway. Ci can form a truncated repressor (Ci(R)/Ci75) or act as an activator (Ci(A)/Ci155) based on Hh gradient to regulate the expressions of target genes. The activity of Ci is mediated by different mechanisms, including processing, trafficking and degradation. While in vertebrate, Glioblastomas (Glis), homologs of Ci, play similar but more complex roles in the regulation of mammals Hh pathway. Hh signaling is responsible for a wide variety of processes during embryonic development and adult tissue homeostasis. Malfunction of Hh signaling could cause various diseases including birth defects and cancers. Enormous efforts were made in the past decades to explore the Hh pathway regulation and the results have provided us important insights into disease diagnosis and therapeutic treatment. In this review, we focus on a small branch of Hh pathway regulation based on studies in the Drosophila system, mainly about Ci degradation, aiming to explain how Ci is modified by different ubiquitin ligases due to the strong or moderate Hh signals and then been subjected to complete or partial degradation by proteasomes. Overall, we intend to offer an overview on how Ci responds to and relays Hh signals in a precise manner to control target genes expressions and ensures proper Hh signal transduction.
学科主题	Cell Biology; Developmental Biology
类目[WOS]	Cell Biology ; Developmental Biology
关键词[WOS]	HEDGEHOG SIGNAL-TRANSDUCTION ; DROSOPHILA IMAGINAL DISKS ; E3 UBIQUITIN LIGASE ; PROTEIN-KINASE-A ; CUBITUS-INTERRUPTUS ; PROTEASOMAL DEGRADATION ; SUBSTRATE RECOGNITION ; COMPLEX ; PHOSPHORYLATION ; PATHWAY
收录类别	SCI
语种	英语
WOS记录号	WOS:000350479100002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/20]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Xiong, Y,Liu, CY,Zhao, Y. Decoding Ci: From partial degradation to inhibition[J]. DEVELOPMENT GROWTH & DIFFERENTIATION,2015,57(2):98-108.
APA	Xiong, Y,Liu, CY,&Zhao, Y.(2015).Decoding Ci: From partial degradation to inhibition.DEVELOPMENT GROWTH & DIFFERENTIATION,57(2),98-108.
MLA	Xiong, Y,et al."Decoding Ci: From partial degradation to inhibition".DEVELOPMENT GROWTH & DIFFERENTIATION 57.2(2015):98-108.