Structural dissection of Hippo signaling

	Structural dissection of Hippo signaling
	Shi, ZB; Jiao, S; Zhou, ZC
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2015
卷号	47 期号:1 页码:29-38
关键词	Hippo pathway three-dimensional structure protein-protein DNA interaction regulatory mechanism
通讯作者	Zhou, ZC (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Natl Ctr Prot Sci Shanghai, State Key Lab Cell Biol,Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,zczhou@sibcb.ac.cn
英文摘要	The Hippo pathway controls cell number and organ size by restricting cell proliferation and promoting apoptosis, and thus is a key regulator in development and homeostasis. Dysfunction of the Hippo pathway correlates with many pathological conditions, especially cancer. Hippo signaling also plays important roles in tissue regeneration and stem cell biology. Therefore, the Hippo pathway is recognized as a crucial target for cancer therapy and regeneration medicine. To date, structures of several key components in Hippo signaling have been determined. In this review, we summarize current available structural studies of the Hippo pathway, which may help to improve our understanding of its regulatory mechanisms, as well as to facilitate further functional studies and potential therapeutic interventions.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	ORGAN SIZE CONTROL ; PROTEIN-INTERACTION NETWORK ; TEAD TRANSCRIPTION FACTORS ; TUMOR-SUPPRESSOR LATS1 ; CELL SELF-RENEWAL ; WW DOMAIN ; PROMOTES APOPTOSIS ; CRYSTAL-STRUCTURE ; DROSOPHILA-MELANOGASTER ; PROLIFERATION ARREST
收录类别	SCI
语种	英语
WOS记录号	WOS:000347411100005
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/11]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Shi, ZB,Jiao, S,Zhou, ZC. Structural dissection of Hippo signaling[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2015,47(1):29-38.
APA	Shi, ZB,Jiao, S,&Zhou, ZC.(2015).Structural dissection of Hippo signaling.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,47(1),29-38.
MLA	Shi, ZB,et al."Structural dissection of Hippo signaling".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 47.1(2015):29-38.