Genetic Basis and Neural Mechanism of Autism Spectrum Disorder

	Genetic Basis and Neural Mechanism of Autism Spectrum Disorder
	Li Jing1,2 ; Lin Zhu-Mei 1,2; Zhu Li-Qi1
刊名	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
	2012-10-01
卷号	39 期号:10 页码:952-961
关键词	autism spectrum disorder gene brain function brain function connectivity
ISSN号	1000-3282
通讯作者	Zhu, LQ (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China.
产权排序	1
英文摘要	Autism spectrum disorder (ASD) is a defective mental disease and its core impairments are social function defect, communication defect, restrictive and stereotyped behavior pattern. The paper introduces the genetic basis and neural mechanism of ASD. ASD has high genetic rate, and 5-HT and testosterone of ASD individual are both higher. Neuroimaging studies find that there are some differences between ASD and normal individuals in the structure and function of amygdala, cingulate gyrus, the fusiform gyrus, mirror neurons, prefrontal lobe and other brain areas, but it is inconsistent in the discrepancy direction of some areas' activation patterns. In addition, the results of functional connectivity studies also confirm the hypothesis that the ASD individuals are under-connection. Future research should focus more on how to use the basic research outcomes to put forward effective treatment and training for clinical research.
学科主题	Abnormal psychology
收录类别	SCI
项目简介	This work was supported by grants from National Basic Research Program of China (2010CB8339004) and The National Natural Science Foundation of China (30970911).
语种	英语
WOS记录号	WOS:000310118300003
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/12832]
专题	心理研究所_认知与发展心理学研究室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li Jing,Lin Zhu-Mei,Zhu Li-Qi. Genetic Basis and Neural Mechanism of Autism Spectrum Disorder[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2012,39(10):952-961.
APA	Li Jing,Lin Zhu-Mei,&Zhu Li-Qi.(2012).Genetic Basis and Neural Mechanism of Autism Spectrum Disorder.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,39(10),952-961.
MLA	Li Jing,et al."Genetic Basis and Neural Mechanism of Autism Spectrum Disorder".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 39.10(2012):952-961.