Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether | |
Ji, Chenglong1,2![]() ![]() ![]() | |
刊名 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
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2014-05-01 | |
卷号 | 37期号:3页码:1116-1122 |
关键词 | BDE 47 Mytilus galloprovincialis Toxicological effects NMR Metabolomics |
ISSN号 | 1382-6689 |
通讯作者 | Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Yantai Inst Coastal Zone Res YIC,Key Lab Coastal, Yantai 264003, Peoples R China. hfwu@yic.ac.cn |
产权排序 | [Ji, Chenglong; Zhao, Jianmin; Wu, Huifeng] Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Yantai Inst Coastal Zone Res YIC,Key Lab Coastal, Yantai 264003, Peoples R China; [Ji, Chenglong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
中文摘要 | Polybrominated diphenyl ethers (PBDEs) are widely used as a class of brominated flame-retardants. As a congener of PBDEs, 2,2',4,4'-tetrabromodiphenylether (BDE 47) is the most toxic congener to animals. In this study, we applied metabolomics to characterize the gender-specific metabolic responses in mussel Mytilus galloprovincialis exposed to BDE 47 for 30 days. Results indicated the apparent gender-specific responses in M. galloprovincialis with BDE 47 exposures (1 and 10 mu g/L) at metabolite level. Basically, BDE 47 induced disruption in osmotic regulation and altered energy metabolism in mussels, via differential metabolic pathways. In addition, the hormesis phenomenon was observed in both male and female mussel samples exposed the two concentrations of BDE 47, indicated by the contrarily altered metabolites from two BDE 47 treatments (1 and 10 mu g/L), respectively. Overall, this study confirmed the gender-specific responses to BDE 47 exposures in mussels and suggested the gender differences should be considered in marine ecotoxicology. (C) 2014 Elsevier B.V. All rights reserved. |
英文摘要 | Polybrominated diphenyl ethers (PBDEs) are widely used as a class of brominated flame-retardants. As a congener of PBDEs, 2,2',4,4'-tetrabromodiphenylether (BDE 47) is the most toxic congener to animals. In this study, we applied metabolomics to characterize the gender-specific metabolic responses in mussel Mytilus galloprovincialis exposed to BDE 47 for 30 days. Results indicated the apparent gender-specific responses in M. galloprovincialis with BDE 47 exposures (1 and 10 mu g/L) at metabolite level. Basically, BDE 47 induced disruption in osmotic regulation and altered energy metabolism in mussels, via differential metabolic pathways. In addition, the hormesis phenomenon was observed in both male and female mussel samples exposed the two concentrations of BDE 47, indicated by the contrarily altered metabolites from two BDE 47 treatments (1 and 10 mu g/L), respectively. Overall, this study confirmed the gender-specific responses to BDE 47 exposures in mussels and suggested the gender differences should be considered in marine ecotoxicology. (C) 2014 Elsevier B.V. All rights reserved. |
学科主题 | Environmental Sciences; Pharmacology & Pharmacy; Toxicology |
研究领域[WOS] | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
关键词[WOS] | POLYBROMINATED DIPHENYL ETHERS ; ENVIRONMENTALLY RELEVANT CONCENTRATIONS ; CLAM RUDITAPES-PHILIPPINARUM ; NMR-BASED METABOLOMICS ; EXPOSURE ; SAMPLES ; CELLS ; BDE-47 ; HEALTH ; GILLS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000338598200024 |
内容类型 | 期刊论文 |
源URL | [http://ir.yic.ac.cn/handle/133337/8748] ![]() |
专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
作者单位 | 1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Yantai Inst Coastal Zone Res YIC,Key Lab Coastal, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Ji, Chenglong,Zhao, Jianmin,Wu, Huifeng. Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2014,37(3):1116-1122. |
APA | Ji, Chenglong,Zhao, Jianmin,&Wu, Huifeng.(2014).Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,37(3),1116-1122. |
MLA | Ji, Chenglong,et al."Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 37.3(2014):1116-1122. |
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