Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring

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	Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring
	Han, Xiao 1; Li, Nanxin 1,3; Meng, Qingxuan 1; Shao, Feng 1; Wang, Weiwen2
刊名	NEUROPSYCHOBIOLOGY
	2011
卷号	64 期号:1 页码:9-14
关键词	Maternal immune activation Reversal learning Tumor necrosis factor-alpha Adolescent Schizophrenia
ISSN号	0302-282X
通讯作者	Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
产权排序	2
英文摘要	Maternal immune activation (MIA) produces a variety of behavioral and brain abnormalities in rodent models of several neuropsychiatric disorders. However, it remains controversial whether MIA impairs reversal learning, a basic function of flexibility relevant to those diseases, in offspring. In the present study, we used the Morris water maze to investigate the effects of middle to late gestation stage poly(I:C) challenges on spatial learning and subsequent reversal learning performance in adolescent rats. Maternal poly(I:C) treatment induced deficits in reversal learning without affecting spatial acquisition abilities. In addition, the serum level of the pro-inflammatory cytokine tumor necrosis factor-alpha was increased in MIA rats. This study advances our understanding of how MIA affects adolescent behavior and brain function. Copyright (C) 2011 S. Karger AG, Basel
学科主题	Physiological psychology/Biological Psychology
收录类别	SCI
项目简介	This work was supported by the National Natural Science Foundation of China (grant No. 30670708, 30500158), the National Basic Research Program of China (973 Program, 2007CB512306), the Chinese Academy of Sciences (KSCX2-YW-R-131), the American Psychological Association (Scott Mesh Scholarship for Research in Psychology) and grants to young scientists from the Institute of Psychology, Chinese Academy of Science (O9KF013001).
语种	英语
WOS记录号	WOS:000291025300002
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/11889]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Yale Univ, Dept Psychol, Div Mol Psychiat, New Haven, CT 06520 USA
推荐引用方式 GB/T 7714	Han, Xiao,Li, Nanxin,Meng, Qingxuan,et al. Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring[J]. NEUROPSYCHOBIOLOGY,2011,64(1):9-14.
APA	Han, Xiao,Li, Nanxin,Meng, Qingxuan,Shao, Feng,&Wang, Weiwen.(2011).Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring.NEUROPSYCHOBIOLOGY,64(1),9-14.
MLA	Han, Xiao,et al."Maternal Immune Activation Impairs Reversal Learning and Increases Serum Tumor Necrosis Factor-alpha in Offspring".NEUROPSYCHOBIOLOGY 64.1(2011):9-14.