Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal
	Sun, N ; Li, Y ; Tian, S ; Lei, Y ; Zheng, J ; Yang, J ; Sui, N ; Xu, L ; Pei, G ; Wilson, FAW
刊名	NEUROSCIENCE
	2006
卷号	138 期号:1 页码:77-82
关键词	conditioned place preference manganese-enhanced MRI gamma-band EEG drug craving
英文摘要	The orbitofrontal cortex is involved in the reinforcing effects of drugs of abuse. However, how the dynamic activity in OFC changes during opiate administration and withdrawal period has not been investigated. We first tested the effects of opiates and drug craving with the conditioned place preference paradigm, using manganese-enhanced magnetic resonance imaging and traditional electroencephalograph recording techniques in rats. T1-weighted 2D MRI (4.7 T) was used after unilateral injection of MnCl2 (200 nL, 80 mM) into the right orbitofrontal cortex. The manganese-enhanced magnetic resonance imaging data suggested that the OFC activity decreased during the opiate administration period but recovered increasingly during the withdrawal period. Also, we found decreases and increases in gamma-band (20-100 Hz) activity during the opiate administration and withdrawal period, respectively. Our results showed that orbitofrontal cortex activity decreased during morphine administration and then went up progressively over several days during withdrawal. The time course of the recovery of orbitofrontal activity from inhibition during the withdrawal period may be related to the experience of drug craving. (c) 2005 Published by Elsevier Ltd on behalf of IBRO.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	CONDITIONED PLACE PREFERENCE ; MANGANESE-ENHANCED MRI ; MAGNETIC-RESONANCE ; MORPHINE ; ACTIVATION ; DEPENDENCE ; ADDICTION ; SYSTEM ; BRAIN ; INHIBITION
收录类别	SCI
语种	英语
WOS记录号	WOS:000235947400009
公开日期	2015-07-28
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/4647]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Chinese Acad Sci, Kunming Inst Zool, Lab Primate Cognit Neurosci, Kunming 650223, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 43007, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Chinese Acad Sci, Grad Sch, Hunan, Peoples R China 5.Nanhua Univ, Med Sch, Hunan 412000, Peoples R China 6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 7.Chinese Acad Sci, Kunming Inst Zool, Lab Learning & Memory, Kunming 650223, Peoples R China 8.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Lab Mol Cell Biol, Shanghai 200031, Peoples R China 9.Univ Arizona, Dept Psychol, Tucson, AZ USA 10.Univ Arizona, Dept Neurol, Tucson, AZ USA
推荐引用方式 GB/T 7714	Sun, N,Li, Y,Tian, S,et al. Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal[J]. NEUROSCIENCE,2006,138(1):77-82.
APA	Sun, N.,Li, Y.,Tian, S.,Lei, Y.,Zheng, J.,...&Hu, X.(2006).Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal.NEUROSCIENCE,138(1),77-82.
MLA	Sun, N,et al."Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal".NEUROSCIENCE 138.1(2006):77-82.