Amine Surface Modifications and Fluorescent Labeling of Thermally Stabilized Mesoporous Silicon Nanoparticles

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	Amine Surface Modifications and Fluorescent Labeling of Thermally Stabilized Mesoporous Silicon Nanoparticles
	Xu, Wujun 1; Riikonen, Joakim 1; Nissinen, Tuomo 1; Suvanto, Mika 2; Rilla, Kirsi 3; Li, Bojie 4; Wang, Qiang 4; Deng, Feng 4; Lehto, Vesa-Pekka 1
刊名	JOURNAL OF PHYSICAL CHEMISTRY C
	2012-10-25
卷号	116 期号:42 页码:22307-22314
英文摘要	Mesoporous silicon (PSi) has been shown to have extensive application opportunities in biomedicine, whereas it has frequently failed to produce complex systems based on PSi due to the lack of surface functional groups or the instability of the unmodified PSi surface. In the present study, PSi nanoparticles, stabilized by thermal oxidation or thermal carbonization, were successfully modified by grafting aminosilanes on the surface. The modifications were performed by covalently bonding 3-triethoxysilylpropyl-amine (APTES) or 3-(2-aminoethylamino) propyldimethoxymethylsilane (AEAPMS) on thermally oxidized PSi (TOPSi) and thermally carbonized PSi (TCPSi). These materials were systematically characterized with N-2 ad/desorption, TEM, contact angle, zeta potential, FT-IR, Si-29 CP/MAS NMR, and elemental analysis. To evaluate their application potentials, a fluorescent dye, fluorescein 5-isothiocyanate (FITC), was coupled on the surface of amine-modified nanoparticles. The effects of PSi matrix and surface amino groups on FITC coupling efficiency, fluorescent intensity, and the stability of fluorescence in simulated body fluid (SBF) were investigated. The nanoparticles modified with AEAPMS had higher FITC coupling efficiency than those modified with APTES. FITC-coupled TOPSi nanoparticles also possessed brighter fluorescence and better fluorescent stability in OF. Furthermore, due to the protection caused by the mesoporous structure of PSi nanoparticles, the FITC-coupled TOPSi nanoparticles showed superior photostability in photobleaching experiment.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]	DRUG-DELIVERY ; ELECTRONIC-STRUCTURE ; RHODAMINE-B ; GROWTH MODE ; IN-VITRO ; MICROPARTICLES ; PHOTOSTABILITY ; ENHANCEMENT ; ACETYLENE ; RELEASE
收录类别	SCI
语种	英语
WOS记录号	WOS:000310121000025
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1629]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Univ Eastern Finland, Dept Appl Phys, FI-70211 Kuopio, Finland 2.Univ Eastern Finland, Dept Chem, FI-80101 Joensuu, Finland 3.Univ Eastern Finland, Inst Biomed, Sch Med, FI-70211 Kuopio, Finland 4.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Xu, Wujun,Riikonen, Joakim,Nissinen, Tuomo,et al. Amine Surface Modifications and Fluorescent Labeling of Thermally Stabilized Mesoporous Silicon Nanoparticles[J]. JOURNAL OF PHYSICAL CHEMISTRY C,2012,116(42):22307-22314.
APA	Xu, Wujun.,Riikonen, Joakim.,Nissinen, Tuomo.,Suvanto, Mika.,Rilla, Kirsi.,...&Lehto, Vesa-Pekka.(2012).Amine Surface Modifications and Fluorescent Labeling of Thermally Stabilized Mesoporous Silicon Nanoparticles.JOURNAL OF PHYSICAL CHEMISTRY C,116(42),22307-22314.
MLA	Xu, Wujun,et al."Amine Surface Modifications and Fluorescent Labeling of Thermally Stabilized Mesoporous Silicon Nanoparticles".JOURNAL OF PHYSICAL CHEMISTRY C 116.42(2012):22307-22314.