Important roles of the hyphenated HPLC-DAD-MS-SPE-NMR technique in metabonomics

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Important roles of the hyphenated HPLC-DAD-MS-SPE-NMR technique in metabonomics
	Tang, Huiru 1; Xiao, Chaoni 1,2,3; Wang, Yulan 1
刊名	MAGNETIC RESONANCE IN CHEMISTRY
	2009-12-01
卷号	47 页码:S157-S162
关键词	Hyphenation HPLC DAD SPE NMR MS
通讯作者	Wang, YL (reprint author), Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Magnet Resonance Ctr, State Key Lab Magnet Resonance & Mol & Atom Phys, Wuhan 430071, Peoples R China.
英文摘要	Metabolite identification is a key step for metabonomics study. A fully automated hyphenation of HPLC-diode-array detector (DAD) mass spectrometry (MS) solid phase extraction (SPE)-NMR spectroscopy (HPLC-DAD-MS-SPE-NMR) is one of the most efficient methods to determine the structure of a given unknown metabolite in a complex mixture (metabonome) and hence represents one of the most important analytical techniques for the further development of metabonomics. In this review, some recent applications of this technique in identifying novel and trace metabolites in plant extracts and drug metabolism have been discussed. Modification of this hyphenated technique, enabling multiple trappings of strong polar metabolites for biofluids, needs further development. Copyright (C) 2009 John Wiley & Sons, Ltd.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Multidisciplinary ; Chemistry, Physical ; Spectroscopy
研究领域[WOS]	Chemistry ; Spectroscopy
关键词[WOS]	NUCLEAR-MAGNETIC-RESONANCE ; GLOBAL METABOLIC-RESPONSES ; MULTIVARIATE DATA-ANALYSIS ; SOLID-PHASE EXTRACTION ; MATRICARIA-RECUTITA L. ; HARPAGOPHYTUM-PROCUMBENS ; LIQUID-CHROMATOGRAPHY ; H-1-NMR SPECTROSCOPY ; BIOMARKER IDENTIFICATION ; MOUSE MODEL
收录类别	SCI
语种	英语
WOS记录号	WOS:000272505700022
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/2147]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Magnet Resonance Ctr, State Key Lab Magnet Resonance & Mol & Atom Phys, Wuhan 430071, Peoples R China 2.NW Univ Xian, Coll Life Sci, Xian 710069, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Tang, Huiru,Xiao, Chaoni,Wang, Yulan. Important roles of the hyphenated HPLC-DAD-MS-SPE-NMR technique in metabonomics[J]. MAGNETIC RESONANCE IN CHEMISTRY,2009,47:S157-S162.
APA	Tang, Huiru,Xiao, Chaoni,&Wang, Yulan.(2009).Important roles of the hyphenated HPLC-DAD-MS-SPE-NMR technique in metabonomics.MAGNETIC RESONANCE IN CHEMISTRY,47,S157-S162.
MLA	Tang, Huiru,et al."Important roles of the hyphenated HPLC-DAD-MS-SPE-NMR technique in metabonomics".MAGNETIC RESONANCE IN CHEMISTRY 47(2009):S157-S162.