Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin-dextran as a novel MRI contrast agent

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin-dextran as a novel MRI contrast agent
	Zhang, Zhi 2; He, Rui 1; Yan, Kun 2; Guo, Qian-ni 2; Lu, Yun-guo 2; Wang, Xu-xia 1; Lei, Hao 1; Li, Zao-ying 2
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2009-12-01
卷号	19 期号:23 页码:6675-6678
关键词	Synthesis Evaluation Porphyrin Dextran MRI contrast agent
通讯作者	Lei, H (reprint author), Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China.
英文摘要	5-(4-Aminophenyl)-10,15,20-tris(4-sulfonatophenyl) manganese(III) porphyrin conjugated with dextran was synthesized. Its potential of being used as a tumor-targeting magnetic resonance imaging contrast agent was evaluated in vitro and in vivo. The results demonstrated that the compound has a longitudinal relaxivity (R(1)) higher than Gd-DTPA, low cytotoxicity and binding specificity to tumor cell membrane. (C) 2009 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]	Pharmacology & Pharmacy ; Chemistry
关键词[WOS]	MAGNETIC-RESONANCE ; NMR ; COMPLEXES ; CARCINOMA ; CELLS
收录类别	SCI
语种	英语
WOS记录号	WOS:000271430400039
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/2142]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zhi,He, Rui,Yan, Kun,et al. Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin-dextran as a novel MRI contrast agent[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(23):6675-6678.
APA	Zhang, Zhi.,He, Rui.,Yan, Kun.,Guo, Qian-ni.,Lu, Yun-guo.,...&Li, Zao-ying.(2009).Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin-dextran as a novel MRI contrast agent.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(23),6675-6678.
MLA	Zhang, Zhi,et al."Synthesis and in vitro and in vivo evaluation of manganese(III) porphyrin-dextran as a novel MRI contrast agent".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.23(2009):6675-6678.