An insight into the metabolic responses of ultra-small superparamagnetic particles of iron oxide using metabonomic analysis of biofluids

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	An insight into the metabolic responses of ultra-small superparamagnetic particles of iron oxide using metabonomic analysis of biofluids
	Feng, Jianghua 1,2; Liu, Huili 2; Zhang, Limin 2; Bhakoo, Kishore 3; Lu, Lehui 4
刊名	NANOTECHNOLOGY
	2010-10-01
卷号	21 期号:39 页码:395101-395101
产权排序	第二
英文摘要	Ultra-small superparamagnetic particles of iron oxides (USPIO) have been developed as intravenous organ/tissue-targeted contrast agents to improve magnetic resonance imaging (MRI) in vivo. However, their potential toxicity and effects on metabolism have attracted particular attention. In the present study, uncoated and dextran-coated USPIO were investigated by analyzing both rat urine and plasma metabonomes using high-resolution NMR-based metabonomic analysis in combination with multivariate statistical analysis. The wealth of information gathered on the metabolic profiles from rat urine and plasma has revealed subtle metabolic changes in response to USPIO administration. The metabolic changes include the elevation of urinary alpha-hydroxy-n-valerate, o- and p-HPA, PAG, nicotinate and hippurate accompanied by decreases in the levels of urinary alpha-ketoglutarate, succinate, citrate, N-methylnicotinamide, NAG, DMA, allantoin and acetate following USPIO administration. The changes associated with USPIO administration included a gradual increase in plasma glucose, N-acetyl glycoprotein, saturated fatty acid, citrate, succinate, acetate, GPC, ketone bodies (beta-hydroxybutyrate, acetone and acetoacetate) and individual amino acids, such as phenylalanine, lysine, isoleucine, glycine, glutamine and glutamate and a gradual decrease of myo-inositol, unsaturated fatty acid and triacylglycerol. Hence USPIO administration effects are reflected in changes in a number of metabolic pathways including energy, lipid, glucose and amino acid metabolism. The size- and surface chemistry-dependent metabolic responses and possible toxicity were observed using NMR analysis of biofluids. These changes may be attributed to the disturbances of hepatic, renal and cardiac functions following USPIO administrations. The potential biotoxicity can be derived from metabonomic analysis and serum biochemistry analysis. Metabonomic strategy offers a promising approach for the detection of subtle physiological responses on mammalian metabolism, and can be employed to investigate the potential adverse effects of other nanoparticles and nanomaterials on the environment and human health.
学科主题	波谱分析
WOS标题词	Science & Technology ; Technology ; Physical Sciences
类目[WOS]	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]	Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]	MAGNETIC-RESONANCE-SPECTROSCOPY ; PROTON NMR-SPECTRA ; BLOOD-PLASMA ; NANOPARTICLES ; DAMAGE ; LIVER ; MICE ; RATS ; NEPHROTOXICITY ; PACLITAXEL
收录类别	SCI
语种	英语
WOS记录号	WOS:000281527600001
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/2013]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Xiamen Univ, Dept Phys, Fujian Key Lab Plasma & Magnet Resonance, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.Agcy Sci Technol & Res, Singapore Bioimaging Consortium, Singapore 138667, Singapore 4.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electanalyt Chem, Changchun 130022, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Feng, Jianghua,Liu, Huili,Zhang, Limin,et al. An insight into the metabolic responses of ultra-small superparamagnetic particles of iron oxide using metabonomic analysis of biofluids[J]. NANOTECHNOLOGY,2010,21(39):395101-395101.
APA	Feng, Jianghua,Liu, Huili,Zhang, Limin,Bhakoo, Kishore,&Lu, Lehui.(2010).An insight into the metabolic responses of ultra-small superparamagnetic particles of iron oxide using metabonomic analysis of biofluids.NANOTECHNOLOGY,21(39),395101-395101.
MLA	Feng, Jianghua,et al."An insight into the metabolic responses of ultra-small superparamagnetic particles of iron oxide using metabonomic analysis of biofluids".NANOTECHNOLOGY 21.39(2010):395101-395101.