MRI of stroke using hyperpolarized (129)Xe

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	MRI of stroke using hyperpolarized (129)Xe
	Zhou,X ; Sun,YP ; Mazzanti,M ; Henninger,N ; Mansour,J ; Fisher,M ; Albert,M
刊名	NMR IN BIOMEDICINE
	2011
卷号	24 期号:2
产权排序	第一
英文摘要	Because there is no background signal from xenon in biological tissue, and because inhaled xenon is delivered to the brain by blood flow, we would expect a perfusion deficit, such as is seen in stroke, to reduce the xenon concentration in the region of the deficit. Thermal polarization yields negligible xenon signal relative to hyperpolarized xenon; therefore, hyperpolarized xenon can be used as a tracer of cerebral blood flow. Using a rat permanent right middle cerebral artery occlusion model, we demonstrated that hyperpolarized Xe-129 MRI is able to detect, in vivo, the hypoperfused area of focal cerebral ischemia, that is the ischemic core area of stroke. To the best of our knowledge, this is the first time that hyperpolarized Xe-129 MRI has been used to explore normal and abnormal cerebral perfusion. Our study shows a novel application of hyperpolarized Xe-129 MRI for imaging stroke, and further demonstrates its capacity to serve as a complementary tool to proton MRI for the study of the pathophysiology during brain hypoperfusion. Copyright (C) 2010 John Wiley & Sons, Ltd.
学科主题	生物学
公开日期	2015-07-14
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1866]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
推荐引用方式 GB/T 7714	Zhou,X,Sun,YP,Mazzanti,M,et al. MRI of stroke using hyperpolarized (129)Xe[J]. NMR IN BIOMEDICINE,2011,24(2).
APA	Zhou,X.,Sun,YP.,Mazzanti,M.,Henninger,N.,Mansour,J.,...&Albert,M.(2011).MRI of stroke using hyperpolarized (129)Xe.NMR IN BIOMEDICINE,24(2).
MLA	Zhou,X,et al."MRI of stroke using hyperpolarized (129)Xe".NMR IN BIOMEDICINE 24.2(2011).