Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence
	Tong, Xiaotian 1; Lan, Wenxian 1; Zhang, Xu 2; Wu, Houming 1; Liu, Maili 2; Cao, Chunyang 1
刊名	NUCLEIC ACIDS RESEARCH
	2011-08-01
卷号	39 期号:15 页码:6753-6763
通讯作者	Tong,XT
产权排序	第二
英文摘要	RET protein functions as a receptor-type tyrosine kinase and has been found to be aberrantly expressed in a wide range of human diseases. A highly GC-rich region upstream of the promoter plays an important role in the transcriptional regulation of RET. Here, we report the NMR solution structure of the major intramolecular G-quadruplex formed on the G-rich strand of this region in K(+) solution. The overall G-quadruplex is composed of three stacked G-tetrad and four syn guanines, which shows distinct features for all parallel-stranded folding topology. The core structure contains one G-tetrad with all syn guanines and two other with all anti-guanines. There are three double-chain reversal loops: the first and the third loops are made of 3 nt G-C-G segments, while the second one contains only 1 nt C10. These loops interact with the core G-tetrads in a specific way that defines and stabilizes the overall G-quadruplex structure and their conformations are in accord with the experimental mutations. The distinct RET promoter G-quadruplex structure suggests that it can be specifically involved in gene regulation and can be an attractive target for pathway-specific drug design.
学科主题	波谱分析
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemistry & Molecular Biology
研究领域[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	DIMERIC G-QUADRUPLEX ; I-MOTIF STRUCTURES ; GROWTH-FACTOR GENE ; C-MYC PROMOTER ; PROXIMAL PROMOTER ; INTERACTIVE AGENTS ; TYROSINE KINASE ; FORMING REGION ; THYROID-CANCER ; SMALL-MOLECULE
收录类别	SCI
语种	英语
WOS记录号	WOS:000294555800044
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/1769]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Kay Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Tong, Xiaotian,Lan, Wenxian,Zhang, Xu,et al. Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence[J]. NUCLEIC ACIDS RESEARCH,2011,39(15):6753-6763.
APA	Tong, Xiaotian,Lan, Wenxian,Zhang, Xu,Wu, Houming,Liu, Maili,&Cao, Chunyang.(2011).Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence.NUCLEIC ACIDS RESEARCH,39(15),6753-6763.
MLA	Tong, Xiaotian,et al."Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence".NUCLEIC ACIDS RESEARCH 39.15(2011):6753-6763.