Self-assembled targeted folate-conjugated eight-arm-polyethylene glycol-betulinic acid nanoparticles for co-delivery of anticancer drugs

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	Self-assembled targeted folate-conjugated eight-arm-polyethylene glycol-betulinic acid nanoparticles for co-delivery of anticancer drugs
	Dai, Lin 1; Cao, Xin 1; Liu, Ke-Feng 1; Li, Chun-Xiao 1; Zhang, Gui-Feng 2; Deng, Li-Hong 1; Si, Chuan-Ling 3; He, Jing 1; Lei, Jian-Du 1
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2015
卷号	3 期号:18 页码:3754-3766
ISSN号	2050-750X
英文摘要	In this study, a targeted nanoparticle platform for co-delivery of anticancer drugs based on folate-conjugated eight-arm-polyethylene glycol-betulinic acid (F-8arm-PEG-BA) was first presented. F-8arm-PEG-BA was synthesized by introducing target molecules (folate) and drug molecules (betulinic acid, BA) to hydrophilic molecules (8arm-PEG). Then another anticancer drug, hydroxycamptothecin (HCPT), was encapsulated into the self-assembled nanoparticles from the conjugate by a simple nanoprecipitation method. These F-8arm-PEG-BA/HCPT nanoparticles (NPs) had a small size (similar to 120 nm), acceptable critical aggregation concentration (similar to 64.8 mu g mL(-1)), and high drug loading (similar to 18 wt% BA and similar to 16 wt% HCPT). Compared to the free drugs, the nanoparticles significantly improved the cellular cytotoxicity and exhibited an obvious synergistic effect by the co-delivery of two different anticancer drugs, BA and HCPT. Pharmacokinetics study revealed the nanoparticles could prolong the circulation of BA and HCPT in the blood. In vivo studies indicated that the nanoparticles enhanced tumor targeting and antitumor activity with lower systemic toxicity. In conclusion, F-8arm-PEG-BA/HCPT NPs have great potential for targeted chemotherapy for cancer.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Materials Science, Biomaterials
研究领域[WOS]	Materials Science
关键词[WOS]	POLY(ETHYLENE GLYCOL) ; SURFACE-PROPERTIES ; MEDIATED DELIVERY ; CANCER-TREATMENT ; PARTICLE-SIZE ; RELEASE ; MECHANISMS ; POLYMERS ; RECEPTOR ; PRODRUGS
收录类别	SCI
语种	英语
WOS记录号	WOS:000353656400011
公开日期	2015-07-08
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/16755]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Beijing Forestry Univ, Beijing Key Lab Lignocellulos Chem, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Beijing 100090, Peoples R China 3.Tianjin Univ Sci & Technol, Coll Mat Sci & Chem Engn, Tianjin Key Lab Pulp & Paper, Tianjin 300457, Peoples R China
推荐引用方式 GB/T 7714	Dai, Lin,Cao, Xin,Liu, Ke-Feng,et al. Self-assembled targeted folate-conjugated eight-arm-polyethylene glycol-betulinic acid nanoparticles for co-delivery of anticancer drugs[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(18):3754-3766.
APA	Dai, Lin.,Cao, Xin.,Liu, Ke-Feng.,Li, Chun-Xiao.,Zhang, Gui-Feng.,...&Lei, Jian-Du.(2015).Self-assembled targeted folate-conjugated eight-arm-polyethylene glycol-betulinic acid nanoparticles for co-delivery of anticancer drugs.JOURNAL OF MATERIALS CHEMISTRY B,3(18),3754-3766.
MLA	Dai, Lin,et al."Self-assembled targeted folate-conjugated eight-arm-polyethylene glycol-betulinic acid nanoparticles for co-delivery of anticancer drugs".JOURNAL OF MATERIALS CHEMISTRY B 3.18(2015):3754-3766.