Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives
	Li,Yan
刊名	ORGANIC & BIOMOLECULAR CHEMISTRY
	2015
卷号	13 期号:5 页码:1550-1557
通讯作者	Li,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China. ; liyanb@mail.kib.ac.cn ; zhanghbyd@gmail.com ; xdyang@ynu.edu.cn
英文摘要	A series of novel 2-substituted indoline imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of a substituted benzimidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl or 2-naphthylmethyl group were vital for modulating the cytotoxic activity. Compound 25 was found to be the most potent derivative with IC50 values of 0.24-1.18 mu M, and exhibited cytotoxic activity selectively against MCF-7, SW480, SMMC-7721 and HL-60 cell lines, while compound 26 showed powerful inhibitory activities selectively against SMMC-7721 and A549 cell lines. Compound 25 can induce G2/M phase cell cycle arrest and apoptosis in SMMC-7721 cells.
学科主题	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	CYTOTOXIC ACTIVITIES ; HYBRID COMPOUNDS ; DESIGN ; CHECKPOINT ; INDUCTION ; IODIDES ; ANALOGS ; AGENTS ; TRANS
收录类别	SCI
语种	英语
WOS记录号	WOS:000348212300033
公开日期	2015-07-07
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/20617]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Li,Yan. Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2015,13(5):1550-1557.
APA	Li,Yan.(2015).Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives.ORGANIC & BIOMOLECULAR CHEMISTRY,13(5),1550-1557.
MLA	Li,Yan."Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives".ORGANIC & BIOMOLECULAR CHEMISTRY 13.5(2015):1550-1557.