Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice

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	Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice
	Yuan, Xiao-Ying 1,2; Liu, Wei 1,2; Zhang, Ping 1; Wang, Rui-Yan 1; Guo, Jian-You3
刊名	EUROPEAN JOURNAL OF PHARMACOLOGY
	2010-03-10
通讯作者邮箱	tata1hao@yahoo.com.cn ; guojy@psych.ac.cn
卷号	629 期号:1-3 页码:147-152
关键词	Aloperine Allergic contact dermatitis Tumor necrosis factor-alpha Interleukin-1 beta Interleukin-6
ISSN号	0014-2999
通讯作者	Xiao-Ying Yuan,Jian-You Guo
产权排序	3
合作状况	国内
英文摘要	Allergic contact dermatitis is a prototypic T-cell-mediated cutaneous inflammatory response. Multiple cell types, inflammatory mediators and cytokines are involved in the regulation of immunologic and inflammatory processes in allergic contact dermatitis. Aloperine is an isolated alkaloid found in the plant of Sophora alopecuroides L. It has been clinically proved effective in China for a long time for skin inflammatory diseases such as allergic contact dermatitis. However, the mechanism of aloperine on allergic contact dermatitis is largely unknown. Therefore, the aim of this study was to investigate the effect of aloperine on 2, 4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis in BALB/c mice and the possible underlying mechanisms. The results showed that topical application of DNFB on the car provoked typical allergic contact dermatitis with ear swelling and ear erythema in BALB/c mice. Treatments with 1% aloperine suppressed DNFB-induced increase in ear thickness and ear erythema. Moreover, 1% aloperine treatment significantly decreased the up-regulated mRNA and protein levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) induced by DNFB in ear biopsy homogenates. Our findings suggest that aloperine greatly improves the DNFB-induced allergic contact dermatitis in mice. The therapeutic mechanism might be related to the reduction of TNF-alpha, IL-1 beta and IL-6 production induced by DNFB. (C) 2009 Elsevier B.V. All rights reserved.
学科主题	生理心理学/生物心理学
收录类别	SCI
原文出处	http://www.ncbi.nlm.nih.gov/pubmed/20006963
语种	英语
WOS记录号	WOS:000275004900023
公开日期	2014-06-12
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10079]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
作者单位	1.Gen Hosp Air Force, Dept Dermatol, Beijing 1000142, Peoples R China 2.China Med Univ, Hosp 1, Dept Dermatol, Shenyang 110001, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Xiao-Ying,Liu, Wei,Zhang, Ping,et al. Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2010,629(1-3):147-152.
APA	Yuan, Xiao-Ying,Liu, Wei,Zhang, Ping,Wang, Rui-Yan,&Guo, Jian-You.(2010).Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice.EUROPEAN JOURNAL OF PHARMACOLOGY,629(1-3),147-152.
MLA	Yuan, Xiao-Ying,et al."Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice".EUROPEAN JOURNAL OF PHARMACOLOGY 629.1-3(2010):147-152.