Depression Shows Divergent Effects on Evoked and Spontaneous Pain Behaviors in Rats

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	Depression Shows Divergent Effects on Evoked and Spontaneous Pain Behaviors in Rats
	Shi, Miao 2,3; Wang, Jin-Yan1 ; Luo, Fei1,2,3
刊名	JOURNAL OF PAIN
	2010-03-01
通讯作者邮箱	wangjy@psych.ac.cn ; luof@psych.ac.cn
卷号	11 期号:3 页码:219-229
关键词	Depression fluoxetine pain thermal hyperalgesia unpredictable chronic mild stress
ISSN号	1526-5900
通讯作者	Jin-Yan Wang，Fei Luo
产权排序	1
英文摘要	Although it has been accepted that depression and pain are common comorbidities, their interaction is not fully understood. The present study was aimed to investigate the effects of depression on both evoked pain behavior (thermal-induced nociception and hyperalgesia) and spontaneous pain behavior (formalin pain) in rats. An unpredictable chronic mild stress (UCMS) paradigm was employed to develop a classical depression. The emotional behaviors were assessed by sucrose preference test, open field test, and elevated plus-maze test. The results showed that the depressed rats always exhibited stronger tolerance to noxious thermal stimulation under both normal and complete Freund's adjuvant (CFA)-induced chronic pain conditions, when compared to nondepressed animals. Interestingly, the spontaneous nociceptive behaviors induced by formalin injection were significantly enhanced in rats exposed to UCMS in comparison to those without UCMS. Systemic administration of antidepressant fluoxetine significantly restored the nociceptive behaviors to normal level in depressed animals. An additional finding was that the inflammatory rats tended to display depressive-like behaviors without being exposed to UCMS. These results demonstrated that depression can have different effects on stimulus-evoked pain and spontaneous pain, with alleviation in the former while aggravation in the latter.
学科主题	生理心理学/生物心理学
收录类别	SCI
资助信息	Funded by a NNSF grant, and a grant for young scientists from the Chinese Academy of Sciences to J.Y.W.;NNSF grants, the 100 Talented Plan of the Chinese Academy of Sciences, a grant from the 863 project , and a grant from NIH Fogarty International Center to F.L.
语种	英语
WOS记录号	WOS:000277092100003
公开日期	2014-06-10
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/10073]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China 3.Peking Univ, Dept Neurobiol, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Shi, Miao,Wang, Jin-Yan,Luo, Fei. Depression Shows Divergent Effects on Evoked and Spontaneous Pain Behaviors in Rats[J]. JOURNAL OF PAIN,2010,11(3):219-229.
APA	Shi, Miao,Wang, Jin-Yan,&Luo, Fei.(2010).Depression Shows Divergent Effects on Evoked and Spontaneous Pain Behaviors in Rats.JOURNAL OF PAIN,11(3),219-229.
MLA	Shi, Miao,et al."Depression Shows Divergent Effects on Evoked and Spontaneous Pain Behaviors in Rats".JOURNAL OF PAIN 11.3(2010):219-229.