Family-based designs for genome-wide association studies | |
Ott, Jurg1; Kamatani, Yoichiro2; Lathrop, Mark2,3 | |
刊名 | NATURE REVIEWS GENETICS |
2011-07-01 | |
卷号 | 12期号:7页码:465-474 |
ISSN号 | 1471-0056 |
通讯作者 | Ott, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China. |
产权排序 | 1 |
英文摘要 | Association mapping has successfully identified common SNPs associated with many diseases. However, the inability of this class of variation to account for most of the supposed heritability has led to a renewed interest in methods - primarily linkage analysis - to detect rare variants. Family designs allow for control of population stratification, investigations of questions such as parent-of-origin effects and other applications that are imperfectly or not readily addressed in case-control association studies. This article guides readers through the interface between linkage and association analysis, reviews the new methodologies and provides useful guidelines for applications. Just as effective SNP-genotyping tools helped to realize the potential of association studies, next-generation sequencing tools will benefit genetic studies by improving the power of family-based approaches. |
学科主题 | Social psychology |
收录类别 | SCI |
项目简介 | We are grateful to J. Terwilliger for providing us with unpublished results on his pseudomarker method. Our work was partially supported by the National Natural Science Foundation of China (NSFC) grant no. 30730057 to J.O. |
语种 | 英语 |
WOS记录号 | WOS:000292814500009 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/11524] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Ctr Etud Polymorphisme Humain, Fdn Jean Dausset, F-75012 Paris, France 3.CEA IC Ctr Natl Genotypage, F-91057 Evry, France |
推荐引用方式 GB/T 7714 | Ott, Jurg,Kamatani, Yoichiro,Lathrop, Mark. Family-based designs for genome-wide association studies[J]. NATURE REVIEWS GENETICS,2011,12(7):465-474. |
APA | Ott, Jurg,Kamatani, Yoichiro,&Lathrop, Mark.(2011).Family-based designs for genome-wide association studies.NATURE REVIEWS GENETICS,12(7),465-474. |
MLA | Ott, Jurg,et al."Family-based designs for genome-wide association studies".NATURE REVIEWS GENETICS 12.7(2011):465-474. |
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